Immunology of Asthma
Match each cytokine with its corresponding phenotypic expression of asthma:
IL-9
IL-4
IL-13
IL-5
- Goblet cell metaplasia, bronchial hyper-reactivity (BHR)
- Eosinophil production/activation
- Mast cell growth factor, promotes IL-4 driven Ab production, goblet cell metaplasia
- Development of Th2 immunity, IgG1 & IgE production
IL-9: mast cell growth factor, promotes IL-4 driven Ab production, goblet cell metaplasia
IL-4: development of Th2 immunity, IgG1 & IgE production
IL-13: goblet cell metaplasia, bronchial hyper reactivity (BHR)
Slide 15
IL-5: eosinophil production/activation