When readings go wrong
How it works
Proposed solutions
Bias
Must knows
100

Dark shades of this beauty product on the fingernails can block the light and throw off a pulse oximeter reading.

What is nail polish?

100

A pulse oximeter shines two kinds of light through your fingertip: red and this invisible type, which is also used in TV remotes.

What is infrared?

100

True or False: Altering calibration groups alone would resolve bias in pulse oximetry.

What is False

100

A study by Sjoding et. al found that black individuals are ____ more likely to have occult hypoxemia compared to white individuals

What is 3.2x

100

A healthy person at sea level typically has a pulse oximeter reading in this range, ending at 100%.

What is 95%-100%?

200

When the hands are _________, blood flow to the fingertips drops and the device may struggle to find a good signal.

What is cold?

200

This iron-containing protein in red blood cells is what absorbs the light and lets the device measure oxygen.

What is hemoglobin?

200

What kind of light source can reduce bias from spectral shift?

What is Monochromatic Light Sources 

200

This is when arterial oxygen saturation is lower than 88% while pulse oximeter is reading at a normal peripherial saturation

What is occult hypoxemia

200

The "Sp" in SpO2 stands for this, indicating the reading comes from a pulse oximeter rather than a blood sample.

What is peripheral (pulse oximetry)?

300

Shivering, tremors, or a fidgety patient can cause this type of interference, named for the movement that corrupts the signal.

What is motion artifact?

300

Oxygen-poor hemoglobin absorbs more of this color of light, while oxygen-rich hemoglobin lets more of it pass through.

What is red light?

300

Implementing this technology would allow a pulse oximeter to automatically update its algorithm between individuals with different skin pigmentations?

What is AI

300

What physical effect contributes to different pulse oximeter readings due to different pigment concentrations?

What is absorbance

300

The abbreviation "SaO2" refers to oxygen saturation measured this way, which is considered more accurate than a pulse oximeter.

What is an arterial blood gas (a blood sample)?

400

A widely cited 2020 study found that pulse oximeters can overestimate oxygen levels in patients with this characteristic, sometimes hiding dangerously low readings.

What is darker skin pigmentation?

400

This technique, abbreviated PPG, detects tiny changes in blood volume with each heartbeat and produces the pulse waveform.

What is photoplethysmography?

400

What could be done to enforce that better representation is occurring when generating calibration datasets?

What is Federal Regulations

400

The FDA states that during calibration this percentage of individuals with dark skin pigmentation be part of the study population

What is 15%

400

Below roughly this percentage, an SpO2 reading is generally considered a cause for concern and a reason to contact a doctor.

What is 90%

500

In carbon monoxide poisoning, a standard pulse oximeter can read falsely normal because it mistakes carboxyhemoglobin for this.

What is oxyhemoglobin?

500

This law, named for two scientists, relates how much light a substance absorbs to its concentration and the distance the light travels, and it underlies how pulse oximeters calculate oxygen saturation.

What is the Beer-Lambert law?

500

The new FDA 2025 draft guidelines for pulse oximetry calls for this to improve calibration datasets?

What is Better Representation

500

This effect contributes to the different Sp02 readings a pulse oximeter produces with individuals with different skin pigmentation because of multichromatic light sources

What is spectral shift

500

Pulse oximeters typically have an accuracy margin of about plus or minus this many percentage points, which is why a single reading shouldn't be over-interpreted.

What is 2%?