Quizbowl Fall 2025

P1

200

Which of the following is not a phase II conjugate

• Sulfate
• Glutamate
• Glutathione
• Cholesterol

cholesterol

400

Which of the following is not a characteristic of Phase I reaction?

• Increased polarity
• Decreased hydrophobicity
• Enhanced tissue penetration
• Product is substrate for Phase II reaction

Enhanced tissue penetration

600

Novel agent MU 129 has been found to have a cLogP value of 6.1. Which of the following is a potential consequence

• MU 129 may have difficulty dissolving in the blood
• The cLogP of MU 129 is consistent with most drugs
• The molecule is not expected to cross the blood brain barrier
• The drug is fentanyl

What is MU 129 may have difficulty dissolving in the blood

800

A catalyst will increase the rate of a chemical reaction by:

• Reducing the potential energy of reactant(s)
• Increasing the potential energy of product(s)
• Reducing the activation energy, Ea, of the reaction
• Enabling bypass of the reaction intermediate complex
• None of the above

What is Reducing the activation energy, Ea, of the reaction

1000

Vancomycin powder has a true density of 2g/cm3. When 20g of this powder is placed in a graduated cylinder, the volume measured was found to be 15mL. What is the bulk density of this powder in (g/cm3)?

• 0.5
• 0.67
• 1
• 1.33
• 1.67

What is 1.33

P2

200

This lab test evaluates storage iron

What is Serum ferritin?

400

Limiting the dose of tPA or TNK for acute ischemic stroke regardless of patient weight is to reduce the incidence of

What is intracranial hemorrhage?

600

Which of the following is NOT part of the standard of care for post-MI patients at discharge?

• High intensity statin
• Aspirin
• Amlodipine
• P2Y12 inhibitor

What is Amlodipine?

800

Which of the following are absolute contraindications for kidney transplantation? Select all that apply

• Active infection
• Limited life expectancy
• Active malignancy
• Active drug abuse
• Morbid obesity (BMI>40)
• Psychiatric problems

active infection, active malignancy, active drug abuse

1000

What receptors does amiodarone bind to

• K+ only
• K+ and beta-adrenergic receptors
• Na+, K+, and beta-adrenergic receptors
• Na+,K+, Ca2+, and beta-adrenergic receptors

Na+,K+, Ca2+, and beta-adrenergic receptors

P3

200

How many types of Multiple sclerosis are there?

What is 5?

400

Nonpharmacologic therapy of the epilepsy patient can involve all of the following in the appropriate patient except

• A temporal lobe surgery
• Low glycemic index diet treatment
• Acupuncture
• Vagal nerve stimulator

What is Acupuncture?

600

Which of the following statements regarding the non-nucleoside reverse transcriptase inhibitors (NNRTis) doravirine and rilpivirine is correct?

• Both doracirine and rilpivirine require food for optimal absorption
• Doravirine has a higher risk of QT prolongation compared to rilpivirine
• Rilpivirine is contraindicated with PPIs, but doravirine is not
• Both doravirine and rilpivirine have significan risks of neuropsychiatric side effects

Rilpivirine is contraindicated with PPIs, but doravirine is not

800

Genetic susceptibility to late-onset AD is primarily linked to which of the following

What is Apolipoprotein E4 genotype?

1000

• PA is a 44 yom with chronic low back pain, due to a work-related injury.  He has undergone several surgeries and currently in physical therapy.  He takes Percocet 10/325 1-2 po q6h prn.  When he takes 9 Percocet per day, he rates his pain acceptable at 3-4/10.  Since he consistently needs pain medications, you recommend switching to a long-acting formulation.  However, the MS Contin is the only extended release product covered by worker’s compensation.  Come up with a recommendation for morphine (dose, route frequency). Use 20mg for oxycodone conversion with a Q12H frequency

• TDD = 90 mg PO oxycodone

90mgoxycodone(30mg morphine/20mgoxycodone) = 135 mg PO morphine

• Dose reduction by 25-50% = 67.5 – 101.25 mg morphine 
• FINAL REGIMEN: morphine sulfate ER 15 mg Take 3 tabs PO q12h

Calculations

200

A patient is to receive acyclovir 5mg/kg every 8 hours for an acute outbreak of herpes zoster. What daily dose, in mailgrams, should a 110-pound female receive?

• What is 750mg?
• 110pounds(1kg/2.2 pounds)= 50kg
• 5mg/kg(50kg)=250mg every 8 hours
• Total daily dose: 250mgx3= 750mg per day

400

MH is a 72 year old male patient hospitalized with decompensated heart failure and fever. Cultures are positive for aspergillosis. MH weighs 110kg and will receive 0.25mg/kg per day of amphotericin B (reconstituted and diluted to 0.1mg/mL) by IV infusion. How many milliliters of amphotericin solution are required to deliver the daily dose?

What is 275mL?

0.25mg/kg (110kg)=27.5mg

27.5mg (1mL/0.1mg)= 275 mL

600

• How many grams of sodium chloride would be needed to prepare 30 mL of a solution with an osmolarity of 600 mOsm/L? (MW 58.5; # of particles 2) (1 point) Round to the nearest tenth.

What is 0.5g?

800

• How many grams of zinc oxide powder should be added to 400g of 5% w/w zinc oxide ointment to prepare a 30% w/w zinc oxide ointment? Please round to the nearest whole gram.

What is 143g?

1000

A pharmacist receives a prescription for 1.5% (w/w) hydrocortisone cream using cold cream as the base. She will use hydrocortisone injection (100mg/mL, SG 1.5) to prepare the prescription because she has no hydrocortisone powder in stock. How many grams of cold cream are required to compound 60 grams of the preparation? Round to the nearest one decimal place.

• What is 13.5g?
• 1.5g/100g=xg/60g            x=0.9g or 900mg
• 900mg(1mL/100mg)= 9mL
• SG= 1.5g/mL
• 1.5=xg/9mL             x=13.5g

Brand/ Generic Drugs (HIV/Cardio)

200

3 letter abbreviation for Biktarvy

What is BIC/TAF/FTC?

400

RAL is part of which drug class

What is INSTI?

600

Generic name for a P2Y12 inhibitor drug contraindicated in patients with stroke or TIA

What is Prasugrel?

800

Brand name for dabigatran

Pradaxa

1000

Brand name for CAB/PRV

What is Cabenuva?