ATA Background
The 2015 ATA Guidelines do not recommend routine RAI ablation
What is low and select intermediate risk patients?
Post operative disease status should be considered in deciding whether additional treatment (e.g.radioactive iodine, surgery, or other treatment) may be needed
What is 50 A?
Patients with PTC tumors equal to or greater than 1cm (T1-T3) were followed after
What is a total thyroidectomy and selective therapeutic central compartment neck dissection?
number of patients
What is 129?
A follow up including long term THST with repeat neck ultrasound, suppressed and stimulated Tg measurements, and imaging biopsy studies every
What is 6-12 months?
Recommendations for RAI administration is broad and provides no objective criteria to assist
What is HCP decision-making?
Recommendation 50B: Post operative serum thyroglobulin (Tg) (on THT or after TSH stimulation) can help in assessing the persistence of disease or thyroid remnant and predicting potential future________
What is disease recurrence?
Study objective was to demonstrate the utility of a personalized risk stratification and RAI selection protocol (PRSP) using postoperative
What is Stim Tg and neck ultrasound
Percentage of patients was able to avoid unnecessary RAI using a personalized risk stratification and RAI selection protocol (PRSP)
What is 90%?
a post treatment WBS seven days after treatment for patients receiving
What is RAI?
Difficult for HCPs to decide which patients should or should not be safely _______
What is ablated?
Postoperatively, in most patients Tg should reach its nadir (lowest point) in
What is 3-4 weeks?
Stim Tg and neck ultrasound approximately 3months post surgery classified patients into 3 groups : <1ug/L, 1-5 ug/L, and >5 ug/L which determined
What was RAI recommendation?
There was virtually no risk of residual/recurrent disease during a mean prospective follow-up of this many years
What is 6.2 years?
Although Orlov et al proposed Stim-Tg cutoffs, other studies are needed to determine whether these are optimal
What are cutoff values?
The use of rhTSH in the post-op Stim Tg setting falls within the scope of the
What is diagnostic indication?
50C:The optimal cutoff value for post operative serum Tg or state in which it is measured to guide decision making regarding RAI administration is
What is not known?
Patient criteria for being excluded from the study given their potential interference with thyroglobulin (Tg) assay.
What are detectable anti-thyroglobulin antibodies?
In low and intermediate risk patients, the overall risk for residual/recurrent PTC was
What is <1%?
Methods for evaluating postoperative disease status
What are Serum Tg, Neck US, and Iodine radioisotope scanning?
Recommendation 50 provides an important opportunity to help HCPs to_______
What is risk stratify?
50D:When the extent of the thyroid remnant or residual disease cannot be accurately ascertained from the surgical report or neck US, or when the results may alter the decision to treat or the activity of RAI that is to be administered, this may be useful
What is postoperative diagnostic RAI WBS?
The ATA Risk classification for the patients in the Orlov Study
What are low and intermediate risk patients?
Orlov et al propose using stim Tg and neck US findings, in low and intermediate risk PTC patients, as initial criteria for risk stratification and RAI selection how many months post total thyroidectomy?
What is 3 months?
When performed, pretherapy doagnostic scans should utilize 123I or a low activity of 131I, with the theraputic activity optimally administered within this many hours
What is 72?