Adverse Effects: immunotherapy
bone marrow suppression
What are mTOR inhibitors (sirolimus and everolimus)?
binds to surface antigens on circulating T lymphocytes leading to their depletion and blocks lymphocyte function
What is rATG?
adverse effects are due to the fact that these drugs reach the highest concentrations in the renal cortex and inner ear
What are aminoglycosides?
you cannot give this drug to a patient taking xanthing oxidase inhibitors
What is azathioprine?
bactrim has these AEs on the kidneys
What is crystalluria, AKI, and hyperkalemia?
these drugs are HIGHLY nephrotoxic
What are calcinuerin inhibitors?
inhibit calcineruin => activation of nuclear factor of activated T cells (NFAT) => decrease early cytokine production and activation of T cells
What are cyclosporin and tacrolimus?
What are fluoroquinolones?
These are the drugs we discussed that cannot be used in pregnancy
What are mycophenolate, mTOR inhibitors
these antibiotics work at the 30s subunit
What are aminoglycosides and tetracyclines?
AEs include flu-like symptoms thus patients are premedicated with steroids and antihistamines
What is rATG?
binds FK binding protein and blocks mTOR activity = inhibition of IL driven T cell and B cell cycle progression, proliferation, and AB production
What are sirolimus and everolimus?
this drug, an mRNA synthesis inhibitor, can cause nephritis and ATN if toxicity happens
What is rifampin?
cyclosporin decreases blood levels of this drug which is used for organ transplant rejection prophylaxis
What is myophenolate?
These are the 3 main AEs from fluoroquinolone use.
What are
1. cartilage injury
2. tendinopathy
3. QT prolongation ?
BONUS: Why do fluoroquinolones cause QT prolongation? (think abt elecrolytes)
associated with invasive CMV infection
What is mycophenolate?
binds IL-2 on activated T cells thus inhibiting IL-2 mediated proliferation and differentiation
What is Basiliximab?
inhibits folic acid synthesis by competitively binding DHFR
What is bactrim?
increased immunosuppressant serum concentrations can occur with the co-administration of drugs that do the following two things
What are CYP3A4 inhibitors and dugs that increase P-gp efflux?
BONUS: name these drugs
These are the the antibiotics associated with AIN?
What are bactrim, sulfonamides, and B-lactams?
These are the AEs of basoiximab
What are edema, HTN, and tremor?
inhibits IMP dehydrogenase involved in de novo guanosine biosynthesis in lymphocytes and thus decreases T and B cell proliferation
What is mycophenolate?
antibiotic induced ATN typically happens from use of these two drugs
What are aminoglycosides and vancomycin?
CYP3A4/P-gp inducers can cause a decrease in immunosuppressant concentrations. These are those drugs
these are the abx that work on the 50s subunit
What are clindamycin, erythromycin (macrolides), and linezolid?