Jynarque Safety
Patient's LFTs increase to >2xULN
What is hold Jynarque for 48-72 hours and repeat LFTs?
Chebib et al 2018
PI
Use in patients with a single kidney
What is patients were excluded from TEMPO and REPRISE therefore no data available?
Med Letter:JYN-EFF Use in Patients with a Single Kidney
Genetic testing revealed PKD1 mutation, HCP wants to order an MRI to calculate TKV
What is 18% of patients with truncating PKD1 mutations having mild disease based clinical and imaging assessment (however, it is up to your clinical judgement Dr. X)?
Resource- Genetics Deck slide 16, Lanktree article CJASN 2021
Jynarque FDA approval date
What is April 24th, 2018?
Would do 1 mile open water/ocean swim races
Who is Kimberly?
Patient's eGFR drops 5-10% after initiating Jynarque
What is the hemodynamic effect?
Effect on hepatic cyst growth-identify reference only
What are 2 available Medical Letters JYN-EFF Effect on Hepatic Cyst Growth and JYN_EFF Use in the Treatment of PLD?
Reassess every 2-3 years
What is Mayo classification 1B
Resource -Chebib practical Guide
Cumulative 24-hour suppression of Uosm greater on tolvaptan vs. placebo
What is Reactive deck? slides 116-121
Gobburu et al. NKF poster 2021 (pub 2023)
This MSL has two tattoos on the lower half of the body
Who is Jill?
Determinants of urine volume in ADPKD using tolvaptan
What is a median increase in urine volume of 128%. 24-hour osmolar excretion was strongly associated with 24-hour urine volume.
Kramers et al. AJKD 2018
Supports longer-term treatment effects of tolvaptan
What is Tolvaptan slowed annualized eGFR decline by 1.01ml/min/year per 1.73m2 versus SOC over 5.5 years?
Reference: Zhou et al. 2022
HCP states he/she has a patient in 20s with "stable" eGFR
What is discuss disease progression in young adults and how eGFR is not the only way to assess?
Disease Burden and Disease Progression of Young Adult Patients with ADPKD
Change from BL in 24hr UPCr (derived from 24hr urine collection) at 12 months
What is the primary endpoint for Envision (PII)
Reference: PII trial of sibe in pts with IgAN- NEJM Mathur 2023
This MSL was the reason a server got fired
Who is Alf?
REMS
What is Risk Evaluation and Mitigation Strategies?
Vasopressin antagonism in slowing progression of ADPKD?
What is decreases cAMP and reduces cell proliferation and fluid secretion?
Reference: Promotional Deck
Preferred imaging techniques for estimating Total Kidney Volume
What is CT scan, MRI?
Change from baseline in the eGFR at 12 Months
What is a secondary endpoint for Envision
Reference: PII trial of sibe in pts with IgAN- NEJM Mathur 2023
This MSL’s childhood nickname was Olivia as in Olivia Newton John
Who is Jessica?
Medications used to Reduce tolvaptan-caused polyuria
What is metformn and HCTZ?
Reference: Kramers et al. CJASN 2022
Data on patients younger than 18
What is a Phase 3 interventional clinical trial in 91 participants?
Mekahli et al. CJASN 2023
Responsible for: plasma blast & plasma cell differentiation and survival, antibody class switch and recombination
What is APRIL?
Reference: April in the pathogenesis of Immunoglobulin A Nephropathy: A review of the evidence, 2023 Mathur, J of Clin Med
Messangial hypercellularity, endocapillary hypercellularity, segmental glomerulosclerosis, tubular atrophy/interstitial fibrosis, presents of crescents.
What is MEST-C?
Former cocktail server at Trump Marina casino in Atlantic City
Who is Andrea?