What is the MOA for Intranasal Glucocorticoids?
Shrink engorged nasal mucous membranes
Second Gen Antihistamines
Fenofexadine, Cetirizine, Loratadine, Desloratadine
Codine/Hydrocodone
Respiratory distress, constipation, sedation, N/V
First Gen Antihistamines
Take at bedtime
No alc/CNS depressants, MAOIs = ↑CNS depression
Report any sedation/confusion/hypotension
Antitussive Opioid
respiratory distress
opioid dependency
What is the MOA for Beta Adrenergic Agonists: SABA?
Suppress release of histamine
Ephedrine, Phenylephrine, Oxymetazoline, Tetrahydrozoline
Acetylcystine
Respiratory distress, angioedema, broncospasam, hypotension
Intranasal Glucocorticoids
Aim to deliver throughout the lining of the nasal cavity
Tilt head forward, direct nozzle slightly away from midline to avoid contact w/ septum
Do not blow nose for atleast one min post admin.
PDE5
What is the MOA for Xanthine Derivatives?
Increase levels of energy-producing cAMP
the FIRST line of TB meds administered
Pyrazinamide, Rifampin, Euthmbutol, Isoniazid, Streptomycin
Pyrazinamide
Hepatotoxicity, Polyarthralgia
Non-Opioid Antitussives
Rifampin
Induces P450 cytochrome enzyme
↑ metabolism of Oral contraceptives, warfarin,
Use other forms of contraceptives
What is the MOA for anticholinergics?
tbh idrk this one, so whoever gets it gets a GOLD STARRRRRRRRR
Intranasal Glucocorticoids: First & Second Gen
First: Beclomethasone, Triamcinolone, Budesonide, Flunisolide
Second: Ciclesonide, Fluticasone propionate, Fluticasone furoate, Mometasone
First Gen Antihistamines
Anticolergenic effects: dry mouth, difficulty urinating, constipation, changes in vision
CNS: drowsiness, seizures
CV: hypotension, palpitations, syncope
GI: N/V/D
Decongestants: Oral & Nasal
Severe HTN, cerebrovascular disease, dysrhythmias
Reduce pulmonary arterial pressure by causing the dilation of pulmonary blood vessels
LABA meds with and w/o ICS
Arformoterol, Formoterol, Salmetrol
w/ ICS: Formetrol/budesonide, Formoterol/mometasone, Salmetrol/fluticasone
SABA/LABA
CNS: anxiety, restlessness, insomnia, tremors, headache
CV: palpitations, dysrhythmias
Resp.: rebound bronchospasm
GU: urinary retention
GI: nausea, gastroesophageal reflux
Oral infections
Theophylline
First Gen Antihistamine
Children <2 yrs
Hypersensitive
Narrow angle glaucoma
Renal impairment
Newborn infants
Breastfeeding
Third trimester of pregnancy