there once
The most common cause of nonmegaloblastic macrocytosis is
Alcoholism
A deficiency of intrinsic factor leads to
Pernicious anemia
Which is the better measure of folic acid body stores?
RBC folic acid
A decrease in platelets is called
Thrombocytopenia
Pernicious anemia is associated with all of the following except
Antinuclear antibodies
The majority of cases, cobalamin deficiency is due to a deficiency of
Intrinsic factor
Nuclear to cytoplasmic asynchrony is associated with
Megaloblastic anemia
Which pair can be found in a patient with megaloblastic anemia?
Hypersegmented neutrophils and oval macrocytes
Which bone marrow is characteristic of megaloblastic anemia?
Hypercellular with low M:E ratio
Which parasite is associated with B12 deficiency
Diphyllobothrium latum
A dimorphic population will always cause an increased
RDW
Lead poisoning can lead to:
Acquired sideroblastic anemia
A deficiency in cobalamin leads to impaired
DNA synthesis
Which is not known to inhibit folate synthesis?
Aspirin
Which of these has the best sen/specifity in diagnosing megaloblastic anemia?
Hypersegmented neutrophils
Hypersegmented neutrophils and giant bands are not found in
Iron deficiency
Which tests are most sensitive to decreased levels of cobalamin?
MMA and homocysteine
An elevated methylmalonic acid is only associated with
B12 deficiency
Which of these is NOT a cause of macrocytic anemia
Iron overload
B12 and Folate deficiency can cause a build up of
Homocysteine
Alcoholics can develop macrocytic anemia due to
Folate deficiency
Which is not increased in megaloblastic anemia
Haptoglobin
The liver stores enough folate to meet daily requirements for how long?
3-6 months
Which biochemical is the best indicator of iron stores?
Ferritin
Neural tube disorders are associated with
Folate deficiency