Rheumatology

biology

100

A gene test to identify those with increased risk of allopurinol hypersensitivity reaction

HLA B*58:01

- Allopurinol hypersensitivity syndrome is a rare side effect from allopurinol

- Patients with HLA-B*58:01 are at increased risk 

- High prevalence of gene in ethnic groups: Korean, Han Chinese, Thai, African

-Conditional recommendation to screen high risk populations prior to initiation of allopurinol