Adaptive or Intrinsic
The most important antigen presenting cell for initiating T cell response against protein antigens
What is dendritic cell
IgG and IgM antibodies injure cells by promoting their phagocytosis or lysis and injure tissues by inducing inflammation.
What is type II hypersensitivity
The process by which immature T cells expressing TCR specific for self antigens encounter these antigens in the thymus and the T cells are killed
What is apoptosis
Type of arthritis affects mostly individuals over the age of 50 and is associated with cartilage loss.
What is primary osteoarthritis
The organ responsible for excretion of uric acid
What is the kidney
Cell that can recognize and destroy severely stressed or abnormal cells
What is NK cell
T lymphocytes (Th1, Th17, CD8+CTLs) are the cause of tissue injury
What is Type IV hypersensitivity
The process occuring in the peripheral tissue where lymphocytes that recognize self antigens are rendered functionally unresponsive.
What is anergy
Substance secreted by chondrocytes which degrades type II collagen
What are matrix metalloproteinases
Condition in which there is complete absence of HGPRT resulting in hyperuricemia and neurologic manifestations.
What is Lesch-Nyham syndrome
The best known PAMP (Pattern associated molecular pattern) found in the plasma membrane and endosomal vesicles and which recognizes microbial molecules
What is Toll-like receptor
IgG and IgM antibodies bind antigens in the circulation and the complexes of Ag/Ab deposit in tissues and induce inflammation.
What is Type III hypersensitivity
The type of T cell which functions to prevent immune reactions against self antigen.
What are Tregs or Regulatory T cells
Bony overgrowth which develop at the margins of articular surfaces.
What are osteophytes
What cells of the intrinsic immune system initiate the inflammatory response in acute gout
What are the neutrophils and/or macrophages
Type of T cell which limits immune response and prevents reaction against self antigen
What are treg cells
Injury is caused by Th2 cells, IgE antibodies, and Mast cells. Mast cells degranulate and release mediators which act on vessels and smooth muscle and proinflammatory cytokines recruit inflammatory cells
What is Type I hypersensitivity
Mutation in FOXP3 transcription factor results in what X-linked autoimmune disease?
What is IPEX - immune dysregulation, polyendocrinopathy, enteropathy, X-linked
Prominent osteophytes found at the DIP joints of the hands
What are Heberden’s nodes
Level of plasma urate which is necessary for uric acid crystals to form
What is 6.8 mg/dL
Cell with the ability to phagocytose microbes and protein antigens, process and present to T cells
What are macrophages
Name the mast cell derived amine which causes intense smoother muscle contraction, increases vascular permeability, and stimulates mucus production.
What is histamine
Organ which is an immune-privileged site due to tissues not communicating with the blood and lymph.
What are the testis/eye/brain? Need to name only 1
Floating full-thickness portions of cartilage in the joint space
What are loose bodies
The name of the component of pseudogout crystals
The name of the component of pseudogout crystals