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Physiology
RYTARY
Parkinson's
100
What is the difference between extended and immediate release drugs?
Extended release: prolonged release of the drug in GI tract Immediate release: all drug is released in the GI tract when it gets there
100
Could a dosage of RYTARY less than 145 mg 3X a day benefit the patients?
Yes
100
What type of tremor do PD patients usually have?
resting tremor
200
What is the effect of not having enough dopamine in the indirect pathway?
Inhibition of movement even when you want movement: Bradykinesia
200
What dosages of RYTARY were effective? (145, 245, 390)
All
200
Name three symptoms of PD.
Bradykinesia, tremor, rigidity, shuffling gait, bent over gait, smaller writing, changes in speech, decreased balance, decreased coordination, freezing gait, decreased arm swing
300
What is the protein that accumulates to form Lewy bodies?
alpha-synuclein
300
What date was RYTARY approved by the FDA?
January 7 2015
300
What are the four things that the researchers evaluated the patients with using the UPDRS?
Cognitive function, ADLs, Motor function, and complications with therapy