Stem Cells
What is a stem cell
Stem cells have the ability to become any type of cell in the human body
What is a gene
Genes are small units of information inside our cells that contain instructions for how our bodies develop and function.
What gene editing is used for sickle cell anemia treatment?
CRISPR/CAS-9
2 years
What is the powerhouse of the cell?
Mitochondria
What types of stem cells are there?
Embryonic
Adult
iPSc
Can two people have the exact same genes?
What guides CRISPR/CAS9
CRISPR
What field does COMPASS prepare students for?
Stem cell/regenerative medicine
What types of cells help heal broken bones?
Stem Cells
What are different levels of potency of stem cells?
Unipotent
Totipotent
Pluripotent
Multipotent
What genes are responsible for body patterning?
Hox Genes
What are the molecular scissors of CRISPR/CAS-9?
CAS-9
What does Dr. Georgia research?
Diabetes *stem cell derived beta cells as a means of producing insulin*
How many bones are in the hand?
27
Which type of stem cell potency can be used to create a whole organism?
Totipotent
Whats the nucleotide that is switched in sickle cell anemia?
Guanine is replaced by Adenine
When was the sickle cell therapy licensed to be used in patients?
Dec 2023
What is governing org that funds COMPASS?
CIRM (CA Institute of Regenerative Medicine)
What are the differences between RNA and DNA
single strand vs double helix
2' OH on RNA
U instead of T
Name the four cofactors that reprogram adult cells into stem cells?
Sox2, Oct4, Nanog, Klf
What is the gene that increases breast cancer likelihood?
BRACA
Where is CRISPR naturally found
Bacteria (discovered in yogurt)
How many people are in each COMPASS cohort?
10
Name three amino acids
histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine, alanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, proline, serine, and tyrosine