Law and Order
According to the DEA, what schedule drug is marijuana?
A: Schedule 1
Which receptor(s) do THC bind to?
CB1 and CB2
Are both CB1 and CB2 GPRCs?
A: Yes
Name one biphasic effect of cannabis
A: seizure, anxiety, memory and cognition, psychoactivity, nausea, appetite, reward
Can you get high by eating a marijuana bud?
What year did the so called “War on Drugs” begin? Closest answer wins.
A: June, 1971 (Pres. Nixon)
Name 1 MS symptom that patients claim cannabis alleviates?
A: bladder incontinence tremor, limb spasticity
Which enzyme degrades AEA? 2AG?
A: FAAH degrades AEA, MAGL degrades 2AG
T/F cannabis affects working memory?
A: T
T/F Smoking cannabis is associated the same risk of carcinogens as smoking cigarettes?
A: false
According to the DEA, what schedule drug is CBD with a THC content below 0.1%?
A: Schedule V
What side effects did the CB1 antagonst Rimoabant cause, which led it to be taken off the market?
A: Suicidal ideation
Name three brain structures involved in the mesolimbic reward pathway.
A: VTA, NAc, amygdala, hippocampus, prefrontal cortex
What category of chemicals give marijuana it’s scent?
A: Terpenes
What common household medication attenuates the memory deficits associated with marijuana?
A: Ibuprofen
What is the difference between decriminalization and legalization
Decriminalization- remain illegal, but legal system would not prosecute person for the act. Penalties range from none to a fine. But the production, dealing, and sales of decriminalized drugs is still prosecutable by law.
Legalization- removing all legal prohibitions against the act
Cannabinoids are involved in many problems and processes in the brain. Write down 6 topics the book discussed as connected with cannabinoids. Hint: each chapter title is “Cannabinoids and ___”
A: emotional regulation, psychosis, learning, memory, reward, addiction, body weight, feeding, appetite, nausea, pain, epilepsy, neurodegenerative disorders
What is the difference between an allosteric and orthostatic?
A: Orthostatic is main one, allostatic is second one, binding here changes conformation of binding site.
What are cannabinoid designer drugs?
A: Synthesized compounds that act as CB1 agonists. Have higher affinity than THC for CB1. Ex: Spice, K2.
T/F prenatal cannabis exposure increases the risk of development of schizophrenia and epilepsy.
A: False, but in view of current evidence, cannabis should not be used by pregnant women.