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Define Sepsis
This life-threatening condition is defined as organ dysfunction caused by a dysregulated host response to infection.
Septic shock is characterized by persistent hypotension requiring vasopressors to maintain a MAP of at least this value
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Two sets of these should be obtained before antibiotics if doing so does not delay therapy
blood cultures
Patients with septic shock often develop this acid-base disorder due to impaired tissue perfusion
What is metabolic acidosis
A SOFA score increase of this many points suggests organ dysfunction consistent with sepsis.
2 POINTS OR MORE
This is the recommended first-line vasopressor in septic shock
What is norepinephrine?
This vasopressor may be added to norepinephrine when high doses are needed.
what is vasopressin
This intervention is recommended if adequate MAP cannot be maintained despite fluids and vasopressors and the patient remains hemodynamically unstable
What are corticosteroids?
Describe the components of QSOFA
This screening tool includes altered mental status, respiratory rate ≥22, and systolic BP ≤100 mmHg
Initial fluid resuscitation recommends this amount of crystalloid for hypotension or lactate ≥4 mmol/
What is 30 mL/kg
Persistent lactate elevation after fluid resuscitation suggests ongoing this condition
What is tissue hypoperfusion?
besides antibiotics and fluids, this principle of sepsis management emphasizes identifying and eliminating the underlying infection source as early as possible
What is source control?
Describe Lactate
Elevated levels of this laboratory marker may indicate tissue hypoperfusion in sepsis
Broad-spectrum antibiotics should ideally be administered within this timeframe after recognizing septic shock
What is within 1 hour
This complication of sepsis is characterized by widespread activation of coagulation and bleeding risk
What is DIC?
After adequate fluid resuscitation, persistent hypotension plus a lactate level greater than this value meets the definition of septic shock
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