"SIRS-ly?"
A patient with a temp of 102.2F, HR of 112, and WBC of 16,000 meets this early systemic response criterion.
What is SIRS (Systemic Inflammatory Response Syndrome)?
This gram-positive cocci is a common cause of sepsis, often linked with skin and catheter infections.
What is staphylococcus aureus?
According to the SEP-1 bundle, blood cultures must be obtained before this is administered.
What are antibiotics?
This lab value is elevated in tissue hypoxia and is used to monitor perfusion in septic patients.
What is lactate?
CMS defines septic shock as a known/possible infection, 2 or more SIRS criteria, and this initial lab with the result.
What is a lactate level greater than or equal to 4?
The SIRS criteria require how many abnormal findings for a positive screen?
What is two or more?
This gram-negative rod is notorious for causing sepsis secondary to urinary tract infections, especially in elderly patients.
What is E. coli?
This initial fluid resuscitation volume is recommended in patients with sepsis-induced hypoperfusion.
What is 30mL/kg of IV crystalloids?
Hypotension in septic shock is defined by a MAP less than this threshold.
What is 65mmHg?
The recommended first-line vasopressor when treating septic shock.
What is Norepinephrine or Levophed?
Sepsis is now defined as life-threatening organ dysfunction caused by this dysregulated host response.
What is the body's response to infection?
This fungal pathogen may cause sepsis in immunocompromised or critically ill patients.
What is Candida albicans?
A patient has an antibiotic initiated in the hospital for an infection prior to the presence of severe sepsis. Blood cultures are drawn once severe sepsis is identified. This is known in the CMS SEP-1 world as what?
What is an acceptable delay?
A qSOFA score of this or higher is associated with increased mortality.
What is 2?
This syndrome, seen in menstruating women using tampons, is a type of septic shock.
What is toxic shock syndrome?
This newer bedside tool uses altered mental status, RR greater than or equal to 22, and SBP less than or equal to 100mmHg to identify patients at higher risk for a negative outcome.
What is qSOFA?
This pathogen causes toxic shock syndrome and can lead to rapid sepsis and multiorgan failure.
What is streptococcus pyogenes (Group A Strep)?
SEP-1 looks at this time frame when determining if the patient meets criteria for persistent hypotension.
What is the hour following the completion of the 30mL/kg IV fluid bolus?
A NEWS2 score of 10 or higher should trigger this occurrence.
This adrenal crisis, often caused by meningococcemia, is a deadly form of septic shock.
What is Waterhouse-Friderichsen syndrome?
A patient with possible spontaneous bacterial peritonitis (SBP), 15% bands, HR of 120, and bilirubin of 2.6 meets criteria for this condition.
What is severe sepsis?
This encapsulated bacteria is a major cause of sepsis in asplenic patients.
What is streptococcus pneumoniae?
This required part of the SEP-1 bundle for anyone meeting septic shock criteria could include detailed physical exam findings, documented cardiac ultrasound, or passive leg raise (to name a few).
What is the reperfusion exam or tissue perfusion assessment?
This can be used to calculate the target IV fluid volume in patients with a BMI >30. Don't forget to document!
What is Ideal Body Weight?
This early goal-directed therapy trial changed sepsis management and introduced protocolized care.
What is the Rivers trial?