EPI
BMZ
Dermis
Morphology
100
What are the layers of the epidermis? From superficial to deep
S. Corneum
S. Lucidum
S. Granulosum
S. Spinulosum
S. Basale
100
What are the 2 main disease categories that affect the basement membrane?
1) Subepidermal blistering disorders
2) Interface dermatitis
100
3 components of the extracellular matrix?
Collagen
Elastic fiber
Gylcosaminoglycans
100
What layer of skin is involved? What cell?
Seborrheic keratosis
Neoplasm involving over proliferation of keratinocytes in the epidermis
200
What is the most important substance produced by cells in this layer? (second/third years must be specific)
Bonus: Name of granule it is stored in?
Stratum spinosum produces lipids (ceramides)
Stored/produced by odland bodies/ lamellar granules
200
What intracellular junction connects the epidermis to the dermis in the BMZ
Hemidesmosome
200
What are the 4 dermal cells of importance?
Fibroblasts
Mononuclear phagocytes/Macrophages
Mast cells
Glomus cells
200
Layer? Cell?
Granuloma annulare
Dermal
Histiocytes (granulomatous)
300
What enzyme is essential in formation of the cornified cell envelope? What does it do?
Tissue transglutaminase- 1 cross links proteins and lipids to produce the CCE
300
What is the weakest zone of the BMZ?
Lamina lucida
300
What are the 3 main adnexal structures?
Hair follicle
Sebaceous glands
Sweat glands
300
Layer?
Pustular psoriasis
Epidermal, typically subcorneal
400
Melanin production relies on having sufficient amounts of what element?
Hint: Key enzyme is dependent on this element
Copper
Melanin is produced from tyrosine (precursor) via tyrosinase (copper dependent)
Tyrosine --> DOPA --> DOPAquinone --> Melanin
400
What is the major component of the lamina densa?
Type IV collagen
400
Apocrine glands are primarily located in what locations?
Anogenital, axilla, periumbilical
400
Layer? Key component?
Keloid
Dermal
Excess collagen
500
c-kit activation is required for what? (2)
Mutations in this gene are associated with what? (2)
C-kit (CD117) is a receptor tyrosine kinase needed for melanocyte development and migration
c-kit mutations are a/w acral and mucosal melanomas
500
BP180 is the target antigen in both bullous pemphigoid and anti-BP mucous membrane pemphigoid, but what is the difference?
BP targets the NC16A terminus of BP180 which is part of the basal keratinocyte zone of the BMZ
MMP targets the C-terminus which is part of the lamina lucida
500
What vitamin is essential for the production of collagen?
Bonus: Deficiency leads to what disease?
Vitamin C
Lysyl hydroxylase and proline hydroxylase catalyze the crosslinking of collagen and are dependent on vitamin C
Deficiency --> Scurvy
500
Intraepidermal or subepidermal?
Subepidermal
Note the scarring, intraepidermal blistering disorders do not scar