Types of Skin Toxicities
What is the term for peeling or shedding of the outer layer of skin?
Desquamation
Which class of chemo drugs is most associated with hand-foot syndrome?
capecitabine and liposomal doxorubicin
What is the most common early sign of radiation dermatitis?
erythema
Which class of drugs is most commonly linked to immune-related skin reactions?
immune checkpoint inhibitors
What should be avoided before radiation sessions to protect the skin?
applying creams, deodorants, or lotions within 4 hours
This type of rash resembles acne and is commonly caused by EGFR inhibitors.
acneiform rash
Which skin condition is characterized by inflammation of mucous membranes during chemo?
mucositis
Name one self-care measure patients should follow during radiation therapy.
avoid deodorants, hot water, or tight clothing
What skin reaction appears in up to 40% of patients on PD-1 inhibitors?
maculopapular rash
What topical agent is recommended for dry, irritated skin?
fragrance-free emollient or barrier cream
What is the medical term for itchy skin?
pruritus
What is a typical nursing intervention for mild chemo-induced rash?
topical corticosteroids or oral antihistamine
What factor increases the risk of skin toxicity from radiation?
treatment over bony prominences or skin folds
What grade of rash involves >30% BSA and impacts daily living?
Grade 3
When should cancer treatment be held or delayed due to skin toxicity?
For Grade 3 or higher toxicities or signs of infection.
What is the name of the condition involving painful, red palms and soles after chemotherapy?
hand-foot syndrome
Name one patient education point regarding skincare during chemotherapy.
use gentle unscented soaps and moisturize regularly
What is the nursing management for moist desquamation?
Apply non-adherent dressings, maintain hygiene, and monitor for infection.
What is the first-line treatment for mild immune-mediated rash?
oral antihistamine or topical corticosteroids
How should a nurse educate a patient receiving chemotherapy about sun exposure?
use sunscreen, wear protective clothing, and avoid peak sun hours
Which rare skin toxicity can be life-threatening and involves widespread skin sloughing?
toxic epidermal necrolysis
What chemo-related skin toxicity presents with hyperpigmentation along the veins?
flagellate erythema or chemo-induced hyperpigmentation
How soon after starting radiation does skin toxicity typically appear?
Within 1–2 weeks.
Name one life-threatening skin reaction to immunotherapy.
Stevens-Johnson Syndrome or TEN
Which grading tool is commonly used to assess severity of skin reactions?
CTCAE – Common Terminology Criteria for Adverse Events