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Diabetes
Metabolic Stress Response
snoRNA
Procedures
100
The principle hormone that regulates the uptake of glucose from the blood into most cells
What is Insulin?
100
A possible result of cellular lipotoxicity
What is cell death?
100
The abbreviation "sno" as in snoRNA
What is small nucleolar RNA?
100
The gene L13a encodes for this type of protein
What is ribosomal?
200
The leading cause of death in people with diabetes
What is Cardiovascular disease?
200
One type of metabolic stress
What is oxidative stress?
200
Location within DNA where snoRNAs are found
What is intronic region?
200
Experimental technique where the expression of an organism's gene is reduced
What is gene knockdown?
300
Estimated number of people in the United States believed to have diabetes
What is 27 Million?
300
The function of adipoctyes
What is fat storage?
300
The technique used to cause mutations in snoRNAs
What is retroviral promoter trap mutagenesis?
300
One advantage of using cells in culture
What is inexpensive/fast?
400
Diabetes fall under this broad group of diseases
What is metabolic disease?
400
The frequency out bodies undergo metabolic stress
What is everyday?
400
The cells used to screen for genes critical for lipotoxic response
What are Chinese hamster ovary cells?
400
The cells with the three mutant snoRNAs were able to survive these conditions
What are lipotoxic and oxidative stressful environments?
500
The leading cause of death in people with diabetes
What is Cardiovascular disease?
500
The group of molecules observed to mitigate lipotoxic cell death?
What are antioxidants?
500
Main function of snoRNA
What is guide chemical modifications?
500
The function of the promoter region
What is initiates transcription of a particular gene?