MOA
Dupixent is the first and only dual inhibitor of?
What is IL-4 and IL-13
Loss of smell is also known as?
What is anosmia.
The dose used for CRSwNP?
What is 300mg
What is injection site reactions.
The name of this awesome team?
What is the Snow Sharks.
IL-4 is found on which receptor?
What are type I and type II receptors.
One of the coprimary endpoints that measures on a scale of 0-4 in each nostril?
What is bilateral endoscopic nasal polyps score (NPS).
Commercial patients may have a $0 copay once this is activated?
What is the DMW Copay card.
The AE that had 14 patients in the Dupi arm?
What is arthralgia.
Sharks have keen olfactory senses are able to detect as little as one part per million of what in seawater?
What is blood.
The airways that Dupixent target inflammation in CRSwNP and asthma?
What are the upper and lower airways.
The change from baseline at week 24 in nasal congestion/obstruction (NC) score averaged over 28 days?
What is the coprimary endpoint/51%.
DMW may provide injection training for patients at home, over the phone, or video?
What is Nursing Support.
The Injection site reactions cluster includes?
What is injection site reaction, pain, bruising and swelling.
Baby sharks are known as?
What are pups.
What is B cell isotype switching to produce IgE.
Opacification is measured by what score?
What is the Lund McKay-CT score.
The Rx is triaged to where to be dispensed/shipped to a patient?
What is the Specialty Pharmacy.
In the safety pool the proportion of subjects who discontinued treatment due to AE was 2% in which group?
What is the Dupxient Q2W group.
Shark skeletons are made of?
What is cartilage.
Blocking IL-13 reduces what structural changes? (List a min of 3)
What is (any 3 of these): Mucus hypersecretion, globet cell hyperplasia, airway smooth muscle hypertrophy, collagen disposition, epithelial barrier disruption, nitric oxide production
The % change in NC score through week 52 in trial 2?
What is 54% improvement.
Dupixent copay card has a maximum annual coverage of?
What is $13,000.
Background therapy for both arms included?
INCS (inhaled nasal corticosteroids)/Mometasone furoate nasal spray.
The amount of teeth a shark has?
What are thousands.