Heart Failure
Calcium Sensitizer that inhibits phosphodiesterase III and increases contractility
Pimobendan
Phosphodiesterase-5 Inhibitor
Sildenafil
Class III agent, increases ERP, K+ channel inhibitor
Sotalol
Thick ascending loop of Henley, inhibits NKCC transport, potassium losing loop diuretic
Furosemide
Shuts down the common pathway and reversed with Protamine Sulfate
Heparin
The only labeled use Ace Inhibitor in vet med
Enalapril
Calcium Channel Antagonist that vasodilates but allows reflex tachycardia.
Amlodipine
Class IV agent, CCB, decrease heart rate and contractility
Diltiazem
Type of diuretic that works on the distal convoluted tubule, retains Ca+, losses K+
Thiazides
Blocks Vit K epoxide reductase
Warfarin
Alpha and Beta blocker that helps protect the heart
Carvedilol
Limited use Nitrate drug applied topically as a cream.
Nitrogylcerin
Reduce adrenergic activity on the heart
Class II agents
Aldosterone antagonist, use caution with ACE inhibitors, potassium sparing
Spironolactone
Prodrug that inhibits ADP
Clopidogrel
The calcium channel blocker used in heart failure
Diltiazem
Prazosin
Class IA agent used in dogs and horses, useful in re-entrant arrhythmias
Quinidine
inhibits carbonic anhydrase enzyme, not used for a diuretic, decreases aqueous humor
Acetazolamide
Used for post surgical bleeding in dogs and cats, but causes vomitting in most dogs.
Tranexamic acid
hypokalemia and hypercalcemia increase toxicity
Digoxin
Activates the RASS in dogs only
Amlodipine
Class IB agent, decreases ERP, blocks inactivated sodium channels
Lidocaine
IV diuretic used before brain and eye surgery
Mannitol
Used topically to activate platelets
Collasate