SSRIs/Stroke

HALF-LIVES, FULLER LIVES

100

This SSRI has the longest half-life.

Fluoxetine (Prozac)

200

This SSRI has the shortest half-life

Fluvoxamine (Luvox)

300

GI distress is caused by an increase in this gut function by serotonergic activity

Motility

400

DAILY DOUBLE:

The bleeding caused by SSRIs is caused by affecting this clotting activity 

Platelet

500

You may see a worsening of this mental illness with administration of an SSRI

Mania in Bipolar depression

THE NAME GAME

100

This 2011 study showed promise in 118 patients after 20mg of fluoxetine post-stroke

FLAME: Fluoxetine for motor recovery after acute ischaemic stroke (FLAME)

200

This drug was used in trials for stroke because of its long half-life

Fluoxetine (prozac)

300

This stroke scale is typically used in ERs and wards across the United States

NIH stroke scale (NIHSS)

400

This stroke scale goes by the acronym HAM-D.

Hamilton Depression Rating Scale

500

This study, published in 2019 out of the UK, showed an increased risk of bone fracture and no improvement in functional outcomes after 6 months on fluoxetine vs placebo.

Fluoxetine Or Control Under Supervision (FOCUS)

ENTROPY is UNIVERSAL

100

Consensus on multiple sources agree that about his percent of patients become depressed after a stroke

40%

200

DAILY DOUBLE:

This class of drugs has been shown to slow recovery after stroke

Benzodiazepines

300

Severe stroke is classified as AT LEAST this many points on the NIHSS

20

400

The FLAME trial was conducted for this many months, vs 6 months for the FOCUS trial

3

500

Serotonin on these two classes of cells are postulated to contribute to risk of bone fracture with SSRIs.

osteoclasts and osteoblasts