Receptor Logic
This receptor causes vasoconstriction when activated.
What is α1?
Blocking α1 receptors leads to this vascular effect.
What is vasodilation?
These drugs are used for both hypertension and BPH due to smooth muscle relaxation.
What are α1-blockers?
This side effect is common with α1-blockers when standing up.
What is orthostatic hypotension?
This short-acting α1-blocker requires multiple daily dosing.
What is prazosin?
This receptor acts as the “brake” on norepinephrine release.
What is α2?
Activation of α2 receptors results in this change in NE release.
What is decreased norepinephrine release?
This drug is preferred for BPH due to prostate selectivity.
What is tamsulosin?
This adverse effect limits use of non-selective β-blockers in asthma.
What is bronchoconstriction?
This drug inhibits tyrosine hydroxylase.
What is metyrosine?
Activation of this receptor leads to bronchodilation.
What is β2?
Blocking α2 receptors results in this effect on sympathetic activity.
What is increased sympathetic activity?
This drug is used in hypertension but can cause rebound hypertension if stopped abruptly.
What is clonidine?
This occurs when β-blockers mask hypoglycemia warning signs.
What is masked hypoglycemia?
This drug blocks VMAT and depletes NE stores.
What is reserpine?
Blocking this receptor can cause bronchoconstriction.
What is β2?
This explains why norepinephrine decreases heart rate despite β1 activation.
What is reflex bradycardia?
This β1 agonist is used to increase cardiac contractility.
What is dobutamine?
This severe adverse effect led to discontinuation of reserpine.
What is depression?
This drug blocks NE reuptake.
What is cocaine?
This receptor increases heart rate and contractility when stimulated.
What is β1?
This β-blocker property increases heart rate at rest but decreases it during exercise.
What is intrinsic sympathomimetic activity (ISA)?
his drug is used in pheochromocytoma and irreversibly blocks α receptors.
What is phenoxybenzamine?
This can occur if β-blockers are stopped suddenly.
What is rebound ischemia or hypertension?
This drug increases NE release by only acting as a releasing agent.
What is amphetamine?