Beta Receptors
____ % of Beta Receptors in the myocardium are B1
75 %
Which of the following BB are Non-selective Beta Antagonists?
A. Atenolol
B. Esmolol
C. Propranolol
D. Metoprolol
E. Nadolol
F. Bisoprolol
G. Timolol
H. Pindolol
I. Acebutolol
J. Celiprolol
C. Propranolol
E. Nadolol
G. Timolol
H. Pindolol
Propranolol (Inderal) IV dose:
- _________ mg/kg
0.5 mg/kg
Which of the following BB are Selective Beta1 Antagonists?
A. Atenolol
B. Esmolol
C. Propranolol
D. Metoprolol
E. Nadolol
F. Bisoprolol
G. Timolol
H. Pindolol
I. Acebutolol
J. Celiprolol
A. Atenolol
B. Esmolol
D. Metoprolol
F. Bisoprolol
I. Acebutolol
J. Celiprolol
Match the following with the % of protein binding: 90-95%, 55%, 10%, 5%
Metoprolol = __________
Atenolol = __________
Esmolol = __________
Propranolol = __________
Metoprolol = 10%
Atenolol = 5%
Esmolol = 55%
Propranolol = 90-95%
____ % of Beta Receptors in the myocardium are B2
20 %
What is the standard drug to which all BB are compared to?
A. Atenolol
B. Esmolol
C. Propranolol
D. Metoprolol
E. Nadolol
F. Bisoprolol
G. Timolol
H. Pindolol
I. Acebutolol
J. Celiprolol
C. Propranolol
Propranolol (Inderal) IV dose:
- _______ - _______ increments Q5mins
0.5 - 1.0 increments Q5mins
Which of the following has Renal clearance?
A. Metoprolol
B. Atenolol
C. Esmolol
D. Propranolol
B. Atenolol
Which of the following (TWO) have Hepatic clearance?
A. Metoprolol
B. Atenolol
C. Esmolol
D. Propranolol
A. Metoprolol
D. Propranolol
Which statement is correct?
A. B1 Receptors are more abundant in bronchial and vascular smooth muscle
B. B2 Receptors can be found in adipose tissue and heart muscle
C. B3 receptors decrease inotropic state
D. All the above are TRUE
C. B3 receptors decrease inotropic state
A. B1 Receptors are more abundant in bronchial and vascular smooth muscle - B2 Receptors
B. B2 Receptors can be found in adipose tissue and heart muscle - B3 Receptors
Propranolol (Inderal) (has/lacks) intrinsic sympathomimetic activity and thus is a (pure/partial) antagonist.
lacks; pure antagonist
Oral dose for Propranolol (Inderal)
40-360 mg
How is Esmolol cleared?
Plasma Hydrolysis/RBC Esterases
Which of the following has an active metabolite?
A. Metoprolol
B. Atenolol
C. Esmolol
D. Propranolol
D. Propranolol
T/F: BB act through competitive inhibition, which means they cannot be reversed.
FALSE- they can be reversed
Propranolol (Inderal) decreases the pulmonary first-pass effect of what induction agent?
A. Lidocaine
B. Fentanyl
C. Propofol
D. Rocuronium
D. Succinylcholine
B. Fentanyl
Which is NOT an effect of Propranolol (Inderal)? (Select 3)
A. Myocardial depression
B. Angina Relief
C. Hyperglycemia
D. Sexual dysfunction
E. Bronchodilation
F. Bradycardia
B. Angina Relief - causes angina
C. Hyperglycemia- hypoglycemia
E. Bronchodilation - bronchoconstriction
Metoprolol IV dose range
1-15 mg
normally 1-5 mg titrated to desired effect
Match the following with the half life: 0.15 h, 2-3 h, 3-4 h, 6-7 h
Metoprolol = __________
Atenolol = __________
Esmolol = __________
Propranolol = __________
Metoprolol = 3-4 h
Atenolol = 6-7 h
Esmolol = 0.15 h (aka 9 minutes)
Propranolol = 2-3 h
Chronic administration of BB is associated with a(n) (increase/decrease) in beta receptors.
Chronic administration of BB is associated with a(n) (increase/decrease) in beta receptors.
Which of the following does not have the characteristic of cardiac selectivity?
A. Metoprolol
B. Atenolol
C. Esmolol
D. Propranolol
D. Propranolol
Propranolol (Inderal) IV dose range
1-10 mg
Atenolol IV dose range
5-10 mg
Match the following with the % of 1st pass hepatic metabolism: None, 10%, 60%, 75%
Metoprolol = __________
Atenolol = __________
Esmolol = __________
Propranolol = __________
Metoprolol = 60%
Atenolol = 10%
Esmolol = None
Propranolol = 75%