Esmolol
Esmolol dose:
- Range: _______-_______ mg IV
- Range: 10-80 mg IV
Which of the following does NOT have the characteristic of cardiac selectivity?
A. Metoprolol
C. Bisoprolol
D. Esmolol
B. Carvedilol
Metoprolol would cause less problems in which of the following pts? (Select All)
A. RV Failure
B. COPD
C. PVD
D. HTN
E. Diabetes
B. COPD
C. PVD
E. Diabetes
(Bisoprolol/Nebivolol) is 3.5 times more potent than (Bisoprolol/Nebivolol).
Nebivol is 3.5 times more potent than Bisoprolol
How is Labetalol (Normodyne) metabolized?
glucorionic acid
Esmolol dose:
- Bolus: _______-_______ mg IV
Bolus: 10-15 mg IV
T/F: At higher doses, selectivity increases for B1 Selective Antagonists (Atenolol, Metoprolol, Esmolol, Bisopprolol, Acebutolol, Celiprolol).
FALSE: at higher doses, selectivity is reduced
How many mg/ml is in a vial of Metoprolol?
5mg/mL
Esmolol has as (rapid/short/intermediate) onset and is (short/intermediate/long) acting.
Esmolol has as (rapid [60 seconds]) onset and is (short) acting.
Which of the following is an effect of Labetalol (Normodyne)?
A. Vasoconstriction
B. Vasodilation
C. Reflex Tachycardia
D. Pronounced reflex Bradycardia
B. Vasodilation
does not cause reflex tachycardia
Esmolol dose:
- Prevent periop response: _______-_______ mg/kg
Prevent periop response: 0.5-2 mg/kg
B1 Selective Antagonists (Atenolol, Metoprolol, Esmolol, Bisopprolol, Acebutolol, Celiprolol) diminish myocardial ___________ while preserving the protective effects of ____ activity.
diminish myocardial remodeling while preserving the protective effects of B2 activity.
Which is the MOST selective of the B1 Blockers?
Atenolol (Tenormin)
How many mg are in a 10 mL vial of Esmolol?
100mg/10mL (10mg/mL)
What is the ratio of A:B antagonistic effects of Labetalol (Normodyne)?
1:7
Beta Antagonistic effects are 7x stronger
Esmolol dose:
- Cont. Infusion: _______-_______ mcg/kg/min
Cont. Infusion: 50-300 mcg/kg/min (another slide says 50-200)
T/F: B1 Selective Antagonists (Atenolol, Metoprolol, Esmolol, Bisopprolol, Acebutolol, Celiprolol) have alpha receptor antagonism properties.
TRUE
T/F: Atenolol (Tenormin) is safe to use in pts with DM and asthma
TRUE
Which of the following is not a listed clinical use of Esmolol?
A. Prevent tachycardia/HTN r/t perioperative stimuli (intubation/surgery/emergence)
B. ECT
C. PIH
D. Chronic, Stable HTN
E. Thyrotoxicosis
D. Chronic, Stable HTN
only available IV, not taken at home
Complete the following on clinical uses of Labetalol (Normodyne).
- _______ emergencies
- Severe HTN r/t excessive submucosal administration of _______
- Rebound HTN after __________ withdrawal
- Severe HTN r/t _____________________
- Deliberate ______________
- HTN emergencies
- Severe HTN r/t excessive submucosal administration of Epi
- Rebound HTN after Clonidine withdrawal
- Severe HTN r/t Pheochromocytoma
- Deliberate Hypotension
How much esmolol would you give 2 minutes before laryngoscopy?
150 mg
Which is TRUE of Metoprolol? (Select All)
A. Nonselective B1 Antagonist
B. Substantial hepatic 1st pass effect
C. At lower doses, may become non-selective
D. After PO administration, only 40% reaches the systemic circulation
B. Substantial hepatic 1st pass effect
D. After PO administration, only 40% reaches the systemic circulation
A. Selective B1 Antagonist
B. High Dose = nonselective
Which is the prominent effect of Bisoprolol?
A. Negative Inotrope
B. Negative Chronotrope
C. Negative Dromotrope
B. Negative Chronotrope
Labetalol (Normodyne) is a unique parental & oral antagonist that works as a selective _____ antagonist and non-selective _____ & _____ antagonist.
selective A1 antagonist and non-selective B1 & B2 antagonist.
Fill in the following possible appropriate IV Bolus doses for Labetalol (Normodyne):
- 5 to ____ mg
- ____ mg/kg
- 0.1 to ____ mg/kg
- 20 to ____ mg
- 5 to 10 mg
- 0.25 mg/kg
- 0.1 to 0.5 mg/kg
- 20 to 80 mg