What is Lupus?
Pathophysiology
Clinical Manifestations
Organ Impact
Head-to-Toe Assessment
100

This term describes lupus as a long-term disease with periods of flares and remission

What is a chronic disease?

100

In lupus, the immune system mistakenly targets these substances from the cell nucleus.

What are nuclear antigens?

100

This is the most common symptom reported by patients with lupus.

What is fatigue?

100

This organ system is most commonly affected internally in lupus.

What are the kidneys?

100

This vital sign should be closely monitored due to kidney involvement.

What is blood pressure?

200

Lupus is classified as this type of disease because the immune system attacks the body’s own tissues

What is an autoimmune disease?

200

These cells become activated and produce autoantibodies in lupus

What are B lymphocytes?

200

Lupus arthritis is typically described as nonerosive and often affects these joints.

What are the hands, wrists, and knees?

200

Inflammation of this heart structure causes chest pain that worsens when lying flat.

What is the pericardium?

200

Foamy urine suggests this renal finding.

What is proteinuria?

300

Lupus most commonly affects women in this age group

What is women of childbearing age?

300

These immune products form when autoantibodies bind to self-antigens.

What are immune complexes?

300

This classic rash appears over the cheeks and nose

What is a butterfly rash?

300

This blood abnormality increases the risk of infection in lupus patients.

What is leukopenia?

300

During skin assessment, this rash pattern is most concerning for lupus.

What is a butterfly-shaped rash?

400

Lupus is often called this because it can mimic many other diseases

What is the great imitator?

400

Immune complexes cause tissue injury by activating this inflammatory system.

What is the complement system?

400

These two neuropsychiatric symptoms are part of lupus diagnostic criteria.

What are seizures and psychosis?

400

Long-term steroid use for Lupus increases the risk of this painful bone condition.

What is avascular necrosis?

400

Confusion, seizures, and personality changes may indicate involvement of this system.

What is the central nervous system?

500

This is why diagnosing lupus is challenging

What is multisystem involvement with variable presentations?

500

This explains why lupus causes flares and remissions instead of continuous symptoms.

What is an excitable immune response?

500

This renal complication affects up to 50% of patients with SLE and can lead to kidney failure.

What is lupus nephritis?

500

Organ damage in lupus tends to do this over time, even when symptoms are controlled.

What is accumulate?

500

This psychosocial factor should always be assessed in patients with lupus.

What is coping ability or mental health status?