Axonal Regeneration
What extracellular factors are responsible for decreased CNS axonal regeneration?
myelin proteins, astrocytes, oligodendrocytes, and microglia
What is the structure that is responsible for axonal growth and that can be visualized with f-actin and b-tubulin?
growth cones
What pathway does rapamycin target?
mTOR (mammalian target of rapamycin)
What is a common causes of TBI?
Car accidents, sports injury
To what do axonal regeneration inhibitors bind?
gangliosides
What was the main result of the y-maze cognition test?
mTBI resulted in significant loss of spatial memory while GM1 treatment fully recovered the loss
What effect does the voltage-gated K+ channel inhibitor 4-AP have on the brain?
Enhanced AP conduction and structural recovery in axons and myelin
What is a common symptom of TBI?
Changes in memory, dizziness, sensitivity to light, fatigue, seizures
Where in neurons are gangliosides found?
plasma membrane
What method was used to induce TBI?
closed head weight drop model
What is NLRP1 the main component of that plays a key role in inflammation after TBI?
inflammasome
What is the main cause of secondary injury in TBI?
inflammation