XT/xR
What does the T and R stand for??
What is... T for Tissue (DNA) and R for RNA
What is the difference between xF and xF+?
Which one is better? xF going away SOON!!!! Only xF+ will be run for all liquid biopsies!
What is....difference in number of genes (105 vs 523) sequenced and CT DNA chart with xF+
***xF+ same amount of blood but more information on report
Can the NM/liquid biopsy blood be used for the xG (hereditary) order as well? Or do you need a different kit/blood?
What is...no, you need a different kit. xF/xF+ and NM go to a different lab than xG/CancerNext Expanded (hereditary)
Is Tempus FDA approved?
What is....Yes!!
Tempus xT CDx assay with normal match is FDA approved!
What is PGx?
What is Pharmacogenomics
Can RNA (xR) be added on to an order by emailing me?
What is...no
All assays need to have an order placed by you/DR.
**We can add on IHC/Algos to anything you need by email request.
What percentage of pts will have actionable mutations found in a liquid biopsy that was missed by solid tissue alone?
What is...9%
For my breast peeps...this number increases to 20%!!!!
What color is the Cancver Next Expanded (xG/xG+) kit? What is the TAT?
What is...gold! TAT- 14-21 days AFTER BLOOD RECEIVED
Don't forget consent needed!!
What needs to be on all blood samples?
what is...pts name, DOB (2 identifiers) and date of collection
Why is DPYD and UGT1A1 testing important...
What is.... to determine if the patient can metabolize the drugs recommended, black box label as of 2/2026, can cause TOXICITY
Why is adding RNA important to all xT (DNA) orders?
What percentage of actionable mutations are found through RNA alone?
What is...RNA will find certain mutations DNA alone will miss.
The percentage is 21%!!!
Can the blood from the Normal match sample be used for the xF/xF+ (liquid Biopsy)? Same blood or does the pt need another draw?
What is...yes, same blood can be used for NM and xF/xF+! No extra blood needed!
What is the difference between CancerNext, CancerNext Expanded and CancerNext expanded with RNA? Which one should you order??
what is xG(CancerNext)- 40 common cancers
xG+ (CancerNext)-77 common and rare
*****xG+ RNA(CancerNext, +RNA Insights)- 77 common and rare and more information with upgrading/downgrading, better support of detection
What is CTS ordering? why is this an important way to order?
What is...Comprehensive Therapy Selection...first option in portal to order. This is FDA approved, "future proof" and provides the best results for pts.
What is Tempus PGx TAT?
what is....The fastest on the market!!
3 days from time we get blood in our lab!!
What is a Normal Match (NM) sample and why is this needed with a xT CDx/xR order?
What is...a Normal Match sample is a blood sample that is needed with all solid tissue CDx orders (FDA approved). This provides more accurate results and calls out any potential hereditary mutations. This compares the pts DNA to themselves instead of a "reference" sample. 28% reduction in somatic false positive calls
How many tubes of Blood are needed for xF/xF+, what type of tubes and what is the TAT?
What is...2 Streck tubes and TAT: 6 days (This is New!!) Launches Phase 1 next week!
WOOHOOOO!!!!!!!
DAILY DOUBLE!!!!!!!
What are the 6 hereditary cancers that NCCN recommends to test all pts?
WOOHOOOO!!!
DAILY DOUBLE!!!!!!! 2 Part Question!!!
How many days is "Tempus Blood" good for before Tempus gets it and then after Tempus gets it?
How do you order a PGx test?
What is...automatically added to all xF+ orders!! You don't have to do anything different!
What are the Algorithmic (Algos) Test we offer and do we need addition tissue for testing? Name 2!
Tempus offers 6 algos (Most need RNA and NM to complete) FYI...Can be added on after report is delivered:
Immune Profile Score (IPS),
Homologous Recombination Deficiency (HRD),
Tumor Origin (TO), DPYD, UGT1A1 (PGx!!!) and PurISTSM
No additional tissue is required
Using a ctDNA-guided approach (xF+) was associated with a 56% reduction in the risk of disease progression with early _____ gene mutation detection in Breast cancer patients.
What is....ESR1
Does Tempus offer Free genetic counseling?
What is ...Yes! Information will be on the report
We also offer free family testing for any positive results.
How many assays can be ordered on 1 order form/placed in the portal for a patient at the same time?
what is....all of them! We try to make it as easy as possible for you!
Assays: xT/xR, XF/xF+, CancerNext, MRD
What are the drugs associated with PGx testing? Name 2 of the 5!
what is... 5-FU, capecitabine, Irinotecan, Belinostat, Sacituzumab Govitecan
Please don't ask me to say them, HA!