Items
"Blood laser barrage"; considered the best item in the game
What is Brimstone
The final final boss of the game; comprised of illusions of the bosses Isaac has previously faced on the run
What is Delirium
Can only take one hit of damage; widely considered to be the hardest character to play
What is the Lost
Gained by getting at least 3 of a certain type of item; grants flight and constant blue flies spawning
What is Guppy
Turns every item icon into a question mark; my least favorite curse in the game
What is Curse of the Blind
"Bouncing tears", unlocked by beating Mom's Heart twice
What is Rubber Cement
The boss of Sheol; has a "Mega" form that can be found in the Chest/Dark Room
What is Satan
Starts with the Book of Belial; the disciple who betrayed Jesus
What is Judas
Gained by getting 3 syringes; increases damage
What is Spun
Turns the map into a question mark; shares its name with a playable character
What is Curse of the Lost
"God tears"; unlocked by beating everything with the Lost
What is Godhead
The most hated boss by the community; found on every floor in the "April's Fool" challenge
What is The Bloat
What is ???/Blue Baby
Gained by getting 3 fly-related items; sometimes used to refer to the Devil
What is Beelzebub/Lord of the Flies
Teleports you around the floor randomly and occassionally rearranges certain rooms
What is Curse of the Maze
What is Dr. Fetus
Isaac in his mother's womb; replaces Mom's Heart after killing it 10 times
What is It Lives
Totally randomized character; unlocked by beating Mom's Heart once
What is Eden
Gained by getting 3 of her items; grants a knife that follows right behind you
What is Mother
Makes your health invisible; useless when playing as the Lost
What is Curse of the Unknown
Grants double damage; the head of Edmund McMillen's childhood dog he wanted
What is Cricket's Head
The final boss of Greed Mode; attacks by shooting coins from his body
What is Ultra Greed
The only blindfolded character; starts with Incubus and the Box of Friends
What is Lilith
Gained by getting 3 mushroom items; grants a heart container and a mushroom head
What is Fun Guy
Combines two floors into one
What is Curse of the Labyrinth