The Binding of Jeopardy

Items and Interactions

1

This is the Synergy between Brimstone and Mom's knife. Describe it.

Knife Barrage

2

Rock Bottom calculates stat gains like this.

Hidden stats that get higher/lower depending on the items you take

3

This single item in the game outside of explosion effects has the highest damage multiplier. 

Mega Mush. (4x Dmg Mult.)

4

"Era Walk" is based off of: 

"Time Walk" from MtG

5

You can become effectively invincible permanently with the combination of these items and/or trinkets.

How to Jump + Panic Button

Knowledge Check

1

You can hit the sacrifice room this many times before you have a chance to be sent to the Dark Room.

12

2

With specific items such as The R Key and forget me now, there is a technique that allows you to use the R-key while carrying another active item. Describe this technique.

Fade-Out Swap

3

This was the original Lost unlock method, and the order you had to do it in.

Isaac dies to a Mulliboom in Basement
Maggy dies to a Bomb in Caves
Judas dies to Mom
Azazel dies to Satan

4

Toothpicks Spindown into this item.

Sacred Heart

5

This is the about chance of Henry Spawning.

~0.001% Chance

Game and Fandom History

1

This is the original Zelda challenge in Isaac.

I Rule!

2

This unused character was a stand-in for The Keeper in the files.

Old Man Keeper

3

This is Mom's full actual name.

Magdalene O. Moriah

4

Name 3 popular Isaac creators that popularized the game before Afterbirth.

(I'll take certain answers but here is what I'm thinking)
NorthernLion
Hutts
Sinvincta
CobaltStreak
Olexa
TearsofGrace

5

This Easter egg only applies after achieving "Dead God"

Isaac singing "Jesus Loves You"

Pop Culture and Biblical References

1

TBoI is based off of the story of Isaac and Abraham, where:

The story of TBoI plays out almost 1 for 1

2

Azazel represents this part of Isaac.

Being "The Scapegoat"

3

The character and boss "Bob" is likely based off of this.

"Bob's your uncle" (A further explanation can be asked)

4

The scrapped character originating from the Antibirth mod was originally based on this character and their fate. Name both.

Edith (Lot's Wife), who turned into a pillar of salt after looking back at Sodom's destruction.

5

In the Antibirth mod, "The Witness" (now known as "Mother") was based off of this in the Bible.

In the New Testament Book of Revelation, two figures referred to as "the witnesses" were sent to preach on Earth before the "end of days".

Misc.

1

This fan artist known for making Suggestive drawings of certain Isaac characters and bosses is now a main designer on the team.

NotYourSagittarius

2

This occurs upon starting a Victory Lap after the 3rd.

You turn into the Lost

3

The Challenge "Cantripped" was majorly adjusted in an update. This change being:

You can only spawn Active Items from the Cards spawned in the challenge (Used to be able to spawn passives)

4

This Boss is bugged when using "Delirious".

Skinless Hush

5

This many pill types can appear on a run.

13