Of course we gave it a lot of names...it was all we could see
Internal regulation
Cancer Connection
100
Old term (still used) for the stage when the cell is NOT in mitosis
What is interphase
100
Final stage when the new nuclear envelopes form and chromosomes de-condense
What is Telophase
100
Isolated from frog oocytes, this mixture could cause other cells to enter mitosis
What is MPF (maturation promoting factor)
100
Often over expressed on breast cancer cells, this can lead to overstimulation of growth in cancer
What is Her-2 or EGF receptor?
200
Two terms for nuclear division and cytoplasmic division
What are Mitosis and Cytokinesis
200
At this stage, chromosomes are clearly lined up equidistant between the poles of the mitotic spindle
What is Metaphase
200
Concentration of this protein builds up slowly, then rapidly decreases
What is cyclin
200
simple alpha-numerical for a major regulator of the cell cycle that signals the cell to die if a checkpoint fails.
What is p53?
300
The section of the cell cycle during which commitment to DNA Replication occurs
What is G1
300
The nuclear envelope begins to break down and chromosomes start to be visible
What is Prophase
300
A serine/threonine kinase that is regulated by cyclin(s)
What is CDK or Cyclin-dependent kinase
300
An altered chromosome named after a city that creates a new protein-tyrosine kinase that leads to leukemia
What is the Philadelphia Chromosome?
400
Name for the stage in which the chromosomes are replicated
What is S-phase
400
Chromosomes begin to separate during this phase
What is Anaphase
400
These temperature-sensitive mutations helped researchers studying yeast identify proteins important in regulating the cells cycle and cancer.
What are cdc or "cell division cycle" mutations?
400
The target of a vaccine, these viruses make the cell grow and divide and makes proteins that block the cells built-in regulation that should cause it do die.
What are Human Papilloma Viruses (HPVs)
500
The point in the cell cycle of yeast where alpha-factor causes arrest
What is the G1 checkpoint known in yeast as "Start."
500
Nuclear envelope is broken down and chromosomes begin to attach to the mitotic spindle, but are not yet lined up.
What is pro-metaphase
500
Often if a cell fails to pass a 'checkpoint' successfully, this is induced.
What is apoptosis?
500
Many targeted cancer therapies attempt to restore function of this normal cell death pathway, often blocked in cancers.