Hemoglobinopathies
What amino acid is replaced in sickle cell anemia
What tests are used to detect PNH?
Sugar water test, acid serum test, and immunophenotyping
What anomaly has giant plt and neutrophils with round, large, blue inclusions
May-heglin
What is a howell jolly body made of and what is the significance?
DNA, from splenectomized patient
How much do i hate this class
yes
What hemoglobinopaty yields 50-65%A, 35-45%S, and <1%F
Sickle cell trait
Acanthocytes, burr cells, and target cells are hallmark for what anemia?
spur cell anemia / severe liver disease
What disease is known for having many reactive lymphs and tests + for mono spot test
Infectious mono
What is a heinz body made of and its significance
HgB and G6PD deficiency
What is the most common form of hemoglobin?
A1 ( 95-97% and alpha 2 beta 2 )
Hemoglobin barts is made of what
4 gamma chains
What anemia is hallmark for oval macrocytes and asynchrony? also has H.J bodies and hyper segs
Megaloblastic anemia
What disease is contagious in kids, has abnormal lymphs, significant leukocytosis, and is caused by adenovirus or coxsackie virus
Infectious lymphocytosis
What is an auer rod made of and what is the significance
Fused lysosome, leukemia
What are the precursors of heme
protoporphryin and delta aminolevulinic acid
What -opathy yields 50-95% S, 0-50%A, and 2-30% F
Beta thal / HgB S
Gastroenteritis, infections from shigella or E.coli 0157, N/N rbc morph., burr cells, polychromasia, casts in urine
What anemia?
Hemolytic uremic syndrome
What disease is casued by a defiency in B-hexosemindase
Tay-sachs
What anemias can u find pappenheimer bodies
thalessemia, sideroblastic anemia
What inclusion is casued by lead poisoning
Basophillic stippling
What -opathy is known for having target cells, sickle cells, and HgB C crystals
HgB s-c disease
In the US, what is the main cause for Fe deficient anemia?
Blood loss
What disease is caused by a defiency in B-Glucoerebrosidase
Gauchers disease
If you see 2 blue dots at the edge of a cell, what is most likely the inclusion
dohle body
Most common site for bone marrow biopsy
iliac crest of pelvic bone