Program Management
The ___ is responsible for assessment and oversight of the institution’s Program components and facilities.
Who is The IACUC or institutional equivalent?
Personnel who have contact with NHPs or who have duties in NHP housing areas should be routinely screened for this disease.
What is Tuberculosis?
The ___ ___ ___ is a detailed description of the proposed use of laboratory animals.
What is the animal use protocol?
Surgical procedures in the laboratory setting may be categorized as ___ or ___ (USDA 1985).
What are Major and Minor?
The use of ___-___ chemicals and other substances ensures that toxic or unwanted side effects are not introduced into studies conducted with experimental animals.
What are pharmaceutical-grade?
This person is responsible for the health and wellbeing of all laboratory animals used at the institution.
Who is the Attending Veterinarian (AV)?
The use of ___ ___ ___ will often reduce the possibility of occupational injury and cross contamination.
What is good personal hygiene?
___ ___ is the use of manual or mechanical means to limit some or all of an animal’s normal movement for the purpose of examination, collection of samples, drug administration, therapy, or experimental manipulation.
What is physical restraint?
In the case of conditioned-response research protocols, use of a __ __ __ __ __ as positive reinforcement, instead of restriction, is recommended.
What is highly preferred food or fluid?
This type of research often necessitates that animals be managed according to contemporary farm production practices, and natural environmental conditions might be desirable.
What is Agricultural research?
This person bears ultimate responsibility for the Program (although overall Program direction should be a shared responsibility among the IO, AV, and IACUC).
Who is the Institutional Official (IO)?
This is necessary for all personnel involved with the care and use of animals.
What is trained/adequately educated/qualified?
The ___ endpoint is the point at which pain or distress in an experimental animal is prevented, terminated, or relieved.
What is Humane?
These types of surgical procedures on a single animal are acceptable only if they are (1) included in and essential components of a single research project or protocol, (2) scientifically justified by the investigator, or (3) necessary for clinical reasons.
What are multiple major surgical procedures?
In regards to agricultural animals, the differences in research goals may lead to a clear distinction between ___ and ___ research.
What is biomedical and agricultural?
The primary oversight responsibilities in the Program rest with the ___, the ___, and ___.
Who are the IO, AV, and IACUC?
A ___ ___ ___ and/or a health history evaluation before work assignment is advisable to assess potential risks for individual employees.
What is a preemployment health evaluation?
The ___ endpoint of a study occurs when the scientific aims and objectives have been reached.
What is experimental?
Some procedures characterized as ___ may induce substantial postprocedural pain or impairment and should similarly be scientifically justified if performed more than once in a single animal.
What is minor?
Many types of these require international, federal, state, and/or local permits, which may call for an evaluation of the scientific merit of the proposed study and a determination of the potential impact on the population or species to be studied.
What are field investigations?
Interinstitutional _____ have the potential to create ambiguities about responsibility for animal care and use. The participating institutions should have a formal written understanding that addresses the responsibility for offsite animal care and use, animal ownership, and IACUC review and oversight.
What are Collaborations?
Each institution must establish and maintain this type of program.
What is the Occupational Health and Safety Program (OHSP)?
With their inherent potential for unanticipated phenotypes, these are an example of models for which increased monitoring for unexpected outcomes could be implemented (Dennis 1999).
Genetically Modified Animals (GMAs) - particularly fish and mice
The development of animal protocols that involve the use of ___ or ___ regulation requires the evaluation of three factors: the necessary level of regulation, potential adverse consequences of regulation, and methods for assessing the health and well-being of the animals (NRC 2003b).
What are Food and Fluid?
This helps ensure the well-being of the animals throughout a study and may also provide opportunities to refine research procedures.
What is Post Approval Monitoring (PAM)?