It's All in The Numbers
Pool Party
Isaac and His Isaac
๐Ÿ‘๏ธsaac
Before and After
100

The number of keys required to open a Golden Chest behind a Key Block.

2 Keys.

100

Forget Me Now

Devil Room, Devil Beggar, Secret Room, Treasure Room

100

Unlocked by holding 55 Pennies.

Cain

100

โš›๏ธ๐Ÿšผ

hydrogen baby

100

An item typically found in a learning establishment + an active item that makes your destiny

Schoolbag of Crafting

200

The price of Brimstone in the Dark Room's starting room.

2 Red Hearts

200
Lead Pencil

Crane Game, Golden Chest, Treasure Room

200

Unlocked by having 7 or more Red Heart containers at once.

Magdalene

200

๐Ÿซ๐Ÿ‘œ

Schoolbag

200

a reference to Pokรฉmon + a reference to Super Meat Boy

Friendly Ball of Bandages

300

How many volts needed to beat the juice out of a guy.

4.5

300

Holy Mantle

Treasure Room, Angel Room

300

Starts with ONLY 2 Black Hearts.

Dark Judas

300

๐Ÿ’ก

Vibrant Bulb

300

Room restarter + the bosses join your party

D7 Seals

400

The chapter Mega Satan is found in.

6

400

Lemegeton

Devil Room, Library

400

Starts with one Red Heart and one Soul Heart.

Esau

400

๐ŸŽ

Mystery Gift

400

One time KABOOM + This mf lasts for 15 seconds

Mama Mega Blast

500

Which ending is unlocked after defeating Ultra Greedier in Greedier mode?

19

500

Mega Blast

Devil Room

500

DAILY DOUBLE

This character's base speed was changed from 0.85 to 0.9 in Repentance.

Keeper

500

๐Ÿ“•โ”

Book of Secrets

500

A molar taken from the easiest boss + Spins down (effect of Spindown Dice) into Sacred Heart

Monstro's Tooth Picks