Internal Controls: The Backbone of Accuracy
Who’s in Charge? Management’s Responsibilities
The COSO Five: Building a Strong Control System
The COSO Five: Building a Strong Control System
Internal Controls in Action: Science Edition
100

This term describes the systems and processes that ensure accuracy, reliability, and integrity in an organization’s operations and reporting.

What are internal controls?

100

Under SOX Section 404, this group must accept responsibility for the effectiveness of internal controls.

Who is management?

100

This COSO component sets the tone at the top and establishes integrity and ethical values

What is the control environment?

100

This process identifies potential events that could threaten an organization’s objectives.

What is risk assessment?

100

These two genes were identified as the most stable internal controls in OSCC qPCR studies

What are GAPD and TUBB?

200

In qPCR studies, genes like GAPD and TUBB serve this role to ensure expression results are trustworthy.

What are internal control genes?

200

This written document must be provided annually, assessing the effectiveness of internal controls.

What is management’s internal control assessment?

200

This component involves identifying and analyzing potential events that could affect objectives.

What is risk assessment?

200

In qPCR studies, failing to choose a stable housekeeping gene creates this type of risk

What is inaccurate data risk?

200

This internal control DNA was co‑amplified in PCR‑ELISA to ensure test reliability.

What is the internal control sequence?

300

In PCR‑ELISA testing for O. volvulus, this type of control prevents false‑negative results.

What is an internal control DNA sequence?

300

This group must support its evaluation of internal controls with sufficient evidence and documentation.

Who is management?

300

This component includes policies and procedures that help ensure directives are carried out.

What are control activities

300

In PCR‑ELISA testing, internal controls reduce the risk of this misleading outcome.

What is a false negative?

300

This antihistamine served as a positive internal control to validate psychometric test sensitivity.

What is hydroxyzine?

400

This is the primary reason internal controls exist — to prevent errors, fraud, and unreliable outcomes.

What is ensuring accuracy?

400

This party, not management, forms an independent opinion on internal control effectiveness.

Who are the auditors?

400

This COSO component ensures relevant information flows across the organization.

What is information and communication?

400

In the fexofenadine study, using hydroxyzine reduced the risk of this testing failure.

What is undetected impairment?

400

Using internal controls in scientific experiments helps prevent these misleading outcomes

What are false results?

500

In the fexofenadine driving study, hydroxyzine served as this type of control to validate test sensitivity.

What is a positive internal control?

500

This responsibility includes designing, implementing, and maintaining internal controls.

What is management’s duty?

500

This component evaluates whether internal controls are functioning as intended.

What is monitoring?

500

Organizations perform risk assessment to prevent errors, fraud, and operational breakdowns — all part of this broader responsibility.

What is internal control management?

500

Across all three studies, internal controls served this essential purpose — the same purpose they serve in business.

What is ensuring?