What does it do?
The purpose of the unfolded protein response (UPR) is to
To maintain the balance of protein folding in the endoplasmic reticulum.
The unfolded protein response takes place here
The endoplasmic reticulum.
OS9 functions as this
mannose receptor
The function of the proteasome
to degrade proteins that are improperly folded
These are the three UPR signal transducers
PERK, IRE1, and ATF6
This moves proteins through the retrotranslocon
Der1
____ acts as the primary sensor in the activation of the unfolded protein response (UPR).
BiP
When the ER gets too stressed from the buildup of proteins in the ER this happens
apoptosis (cell death)
____provides power for protein extraction
VCP (Valosin-containing protein)
Inositol-requiring enzyme 1 (IRE1) does this
activates the unfolded protein response.
This pathway works in conjunction with the UPR
Endoplasmic reticulum-associated degradation (ERAD)
This functions a the ubiquitin receptor
DSK2
The cytosolic side of PERK functions as a
Kinase
When the UPR gets overloaded in sugar metabolizing cells, and these cells get destroyed, it can lead to this disease.
Diabetes
This protein is activated during the UPR to protect cells from ER stress
Activating Transcription Factor 6 (ATF6)