Therapeutic Hypothermia

TH

100

What is the targeted core temperature?  

32°C – 34 °C (89.6°F – 93.2°F)

            

200

What is the purpose of TH?

Decrease mortality rate and increase neurological outcome

300

On average, cerebral oxygen demand and consumption is reduced by ____.

5% per 1°C

Mechanism of action

100

Cardiac arrest and return of spontaneous circulation (ROSC) results in ______ - ________ injury. 

Ischemia-perfusion 

200

How does TH maintain neuronal integrity? 

Reduces excitatory amino acids (glutamate, glycine)

300

List 3 mechanisms of action involved in TH. 

- Maintains neuronal integrity(reduces excitatory         amino acids)

- Prevents apoptosis

- Decreases brain metabolism and oxidative stress       (lowers cerebral metabolic rate, oxygen and             glucose consumption, lactate levels, free radials)

- Decreases inflammation, cytotoxic edema,                 vasculature damage

Phases of TH

100

Name the three phases of TH.

1) Induction 

2) Maintenance

3) Rewarming 

200

True or False:

Rewarming phase begins 24 hours after patient reaches the targeted core temperature. 

False:

Rewarming phase begins 24 hours after initiating cooling measures. 

300

In the rewarming phase, patient is slowly rewarmed at a temperature increase of __________ until patient reaches 36.0 °C or 37.0 °C. 

0.3°C - 0.5 °C every hour