Early stage lung
These are the components of the proximal bronchial tree on the right and left side
What is the right main bronchus, right upper lobe bronchus, bronchus intermedius, right middle lobe bronchus and right lower lobe bronchus, and the left main bronchus, left upper lobe bronchus, lingular bronchus, and left lower lobe bronchus?
Involvement of this lymph node station with disease, regardless of laterality, corresponds to N2 disease
*need station number and name for credit
The updated 2021 USPSTF lung can screening criteria recommends low dose CT chest for these patients
Who are patients 50-80 years old, 20 pack-year smoking history, who are currently smoking or quit less than 15 years ago
What is teratoma, terrible lymphoma, thymoma, and thyroid (ectopic intrathoracic goiter)
This histologic subtype of mesothelioma is known for having the best prognosis
What is epithelioid?
The efficacy and safety of these two SBRT regimens in treating NSCLC were compared in the RTOG 0915 Phase II trial by Timmerman et al.
In the ANITA trial secondary analysis of patients with lung cancer who underwent post-operative radiation, for what two prognostic patient groups did post-operative radiotherapy and PORT+chemotherapy show an OS benefit for, respectively
What is PORT for pN1 patients and PORT + chemo for pN2 patients?
The adriatic and caspian trials demonstrated the OS benefit of adding durvalumab concurrent with chemotherapy and adjuvantly for which two prognostic groups of SCLC patients, respectively?
These 5 WHO histologic subtypes of thymoma correspond to 10 year disease free survival rates, in descending order from best to worst prognosis
*only get credit for listing all 5 types in order from best DFS to worst DFS*
In addition to the pleura, mesotheliomas can also originate from any of these three tissues
peritoneum, pericardium, and tunica vaginalis
*credit for 2/3
This phase I/II trial demonstrated that 5-fraction SBRT regimens are safe in the treatment of central, T1-2 NSCLC tumors, provided that constraints can be met
What is RTOG 0813?
In the RTOG 0617 trial assessing dose-escalation in advanced NSCLC, only this dosimetric parameter to an OAR was associated with worse overall survival after adjustment for other variables
What is heart V40?
While the CONVERT trial comparing QD versus BID fractionation in SCLC showed no statistically significant difference in OS between the two techniques, what feature of the trial led to BID fractionation remaining as the standard of care?
This is the Masaoka stage of a patient with a biopsy-proven thymoma with evidence of gross disease invading the mediastinal pleura
What is Masaoka stage III?
These are the nodal staging categories for mesothelioma
What is
N0 - no LNs
N1 - ipsi bronchopulm, hilar or mediastinal LNs
N2 - contralat mediastinal, ipsi or contra SCV LNs
*credit for getting 2/3*
In the MD Anderson retrospective experience by Chang et al. describing the safety and efficacy of treating central NSCLC lesions, for patients receiving 70 Gy in 10 fractions, the primary constraint for the trachea, bronchial tree, and heart/pericardium was a Dmax no greater than this value
What is Dmax < 60Gy?
This is the treatment for radiation pneumonitis
What is prednisone 60 mg with slow taper over 6-8 weeks?
Radiation for LS-SCLC should be preferably initiated no later than this cycle of chemotherapy
What is cycle 3?
The MSK retrospective review by Rimner et al (JTO 2023) concluded that for patients with advanced thymic carcinoma, post-operative radiation improved overall survival for patients with these residual tumor classifications
What is R0, R1, and R2 disease
*trick question, all pts had improved OS*
Thiese two organs are blocked from the AP and PA photon fields during delivery of hemithoracic radiation after extrapleural pneumonectomy for malignant pleural mesothelioma
What is the stomach (left side) or liver (right side)?
In the Japanese phase III trial by Saji et al. comparing lobectomy vs segmentectomy for small, peripheral NSCLC tumors, patients who received segmentectomy had double the rate of this clinical outcome compared to those who received lobectomy
What is local relapse?
Among patients with NSCLC, patients/tumors in these three demographic/histologic groups are most likely to have cancers with EGFR mutations
What are non-smokers, adenocarcinomas, and patients of Asian descent
This was arguably the biggest criticism of the landmark intergroup 0096 trial by Turrisi et al. comparing BID to QD radiation fractionation in LS-SCLC
What is non-equivalent biologically effective dose of the two treatment arms
(45Gy in daily fx vs 45 Gy in BID fractions, even though 45gy bid is closer to 60gy with conventional frac in terms of alpha/beta)
For patients with radiographic findings suggestive of a thymoma amenable to surgical resection, this step in disease work-up is not required
What is a biopsy?
In the treatment of malignant pleural mesothelioma, studies evaluating the benefits of delivering prophylactic radiation to the biopsy/procedure tract have consistently demonstrated the following conclusion
What is no clinical benefit?