Early Stage NSCLC
The lingula is an anatomic extension of this pulmonary lobe
What is the left upper lobe?
A patient with a 1.7 cm adenocarcinoma of the right lung that invades the carina with biopsy-proven ipsilateral supraclavicular lymphadenopathy and no other evidence of disease has this TNM stage.
What is T3N3M0?
Among available nodal sampling techniques for lung cancer, a chamberlain procedure or mediastinotomy is uniquely capable of accessing these lymph node stations *number and names of stations*
What are level 5 nodal stations, subaortic or AP window, and level 6 nodal stations, para-aortic
Approximately this percent range of patients diagnosed with thymomas also have concurrent myasthenia gravis
What is 30-50%?
What is T2 disease?
This FEV1 minimum value is required for a patient to be considered for a pneumonectomy
What is 2L?
In 2021, Atkins et al. (JAMA Oncol) published their retrospective cohort analysis of 701 patients with locally advanced NSCLC, and found that exceeding this dose threshold to this OAR was independently associated with increased risk of major adverse cardiac events.
What is V15<10% to the LAD?
These are the approximate 2-year overall survival rates for limited stage and extensive stage SCLC, respectively
What is 40% and 5%
*credit if anything less than 10% for ESCLC and between 45-35% for LSSCLC
Thymomas and thymic carcinomas arise from this cell type
Epithelial cells/epithelioreticular cells (credit for either)
Of all known mesothelioma histologic subtypes, these two subtypes are associated with the worst prognosis
What is sarcomatoid and fibrous?
Chang et al. published their experience from MD Anderson in 2014 describing the safety and efficacy of 70 Gy in 10 fractions to treat centrally located, T1-2 NSCLC. They found that a brachial plexus Dmax over this dose was independently associated with brachial plexopathy
What is 35 Gy?
This chemotherapy agent is typically included as one of two agents for concurrent chemoradiation in locally advanced non-squamous cell lung cancer
What is pemetrexed?
Lambert Eaton Syndrome, a rare paraneoplastic syndrome associated with small cell lung cancer, occurs via an autoimmune targeting of these cellular structures.
What are presynaptic voltage-gate calcium channels?
This is the Masaoka stage of a thymoma that is grossly adherent to mediastinal pleura but has not broken into it
What is Masaoka stage IIB
In the phase II IMPRINT trial, this type of surgery was performed on patients with malignant pleural mesothelioma treated with involved hemithoracic IMRT
What is pleurectomy-decortication?
In the SUNSET trial evaluating 8-10 fraction moderately hypofractionated radiotherapy in early, non-small cell lung cancer, this definition of ultracentral was used as an inclusion criteria
What is PTV touching PBT, esophagus, and/or pulmonary vasculature?
In the LUNG ART trial evaluating post-operative radiotherapy after surgical resection of NSCLC, what clinical/toxicity outcomes were significantly increased and decreased, respectively
What is cardiopulmonary death and mediastinal relapse?
In the phase 3 trial by Takahashi et al. evaluating PCI vs. surveillance in ES-SCLC patients, the group used this imaging surveillance regimen
MRI Brain at 3 mo intervals up to 12 months, then 18 months, and then 24 months
These are the three clinical scenarios in which post-operative radiotherapy should generally be offered for thymic malignancies
What are positive surgical margins, stage III disease, and thymic carcinoma
In the 2020 phase III study by Trovo et al. that randomized patients who underwent lung-sparing surgery with gross residual disease to adjuvant hemithoracic IMRT vs. palliative RT, what was the dose and technique used for adjuvant hemithoracic IMRT?
50Gy/25fx to hemithorax with 60Gy SIB to gross disease
In the I-SABR study evaluating immunotherapy with SBRT for early-stage lung cancer, exploratory analyses showed the greatest benefit of immunotherapy was seen among patients with this lung cancer histologic subtype
What is squamous cell carcinoma?
*need to include up-front resectable to receive credit
In the CONVERT trial evaluating QD vs. BID fractionation in SCLC, this was the spinal cord constraint used in the BID fractionation arm
What is spinal cord D0.1cc < 41Gy?
*credit for saying Dmax <41Gy
*credit for saying Dmax <36Gy
In the 2017 NCDB study by Jackson et al. (J Thoracic Oncol) evaluating 4,056 patients who underwent resection for thymoma or thymic carcinoma, post-operative radiotherapy was independently associated with this clinical outcome for patients with high risk of recurrence
What is overall survival?
What is pleurectomy/decortication?