Renal Phys (Tubular Reabsorption & Secretion) [lecture 4 1055-1081]
Reabsorbs filtered peptides and low-molecular weight proteins
proximal tubule
Location of variable H2O reabsorption under the control of vasopressin
distal tubule & collecting duct
stimulates reabsorption of urea from the inner medullarycollecting ducts
ADH
Responce to a decrease in plasma calcium
parathyroid glands are stimulated & Thyroid C cells are inhibited
This Pizza Hut item was a calzone-style pizza that made a brief comeback during March Madness 2019.
What is the P’Zone
Produces a concentration gradient for urea that favors passive reabsorption
reabsorption of H2O in the proximal tubule
Controls the amount of Na filtered
GFR regulation
This type of vasopressin binds to receptor on the prioncipal cells of the distal and collecting tubule
blood-borne
converted into pre-vitamin D3 by UV light in the skin
provitamin D3
The original name of Burger King when it was founded in 1953 in Jacksonville, Florida.
What is Insta-Burger King?
Substance leaves tubular fluid via luminal membrane > passes through cytosol of tubular cells > crosses basolateral membrane into interstitial fluid > diffuses through interstitial fluid > penetrate the capillary wall to enter blood plasma
trans-epithelial transport
Increases H2O reabsorption by kidney tubules
vasopressin
makes distal and collecting ducts permeable to water
vasopressin
Ca2+ binding proteins
calbindins
This regional chain, founded in 1921, is credited with being the first fast food hamburger chain in the U.S.
What is White Castle?
proteionuria caused by a lack of reabsorption
Beta2- or alpha1- microglobulinuria
Usage examples of carbonic anhydrase inhibitors (5)
heart failure (rarely), acute mountain sickness, metabolic alkalosis, glaucoma, epilepsy
phosphorylates aquaporin 2 channels located in the jcytoplasm
PKA
Results in osteodystrophy and calcification (heart & bone vessels)
secondary hyperparathyroidism
This Taco Bell item featured a fiery red shell and spicy lava sauce, and fans still try to recreate it at home.
What is the Volcano Taco?
Size of molecules that are freely filtered at the glomerulus
10 kDa
Produced by adrenal cortex to stimulate kidneys
aldosterone
Features of cortical nephrons (3)
glomeruli in outer cortex, loop of Henle dips slightly into medulla, peritubular capillaries as complex network woven around tubule
Percentage of the daily filtered load reabsorbed by the renal tubules
75-85%
In 1993, this fast food chain introduced a short-lived burger called the “Arch Deluxe,” marketed as a “burger with grown-up taste.”
What is McDonald’s?