Final Jeopardy
100
This character is sometimes known as the Ultimate Despair, a name which also refers to the group of high schoolers that ended the world in her name.
Who is Junko Enoshima? 
200
In Fire Emblem: Three Houses, this woman rules over the Church of Seiros as its archbishop, and is in reality the legendary Seiros herself.
Who is Rhea? 
300
This 2021 film directed by the legendary Masaaki Yuasa centers on the friendship between the titular character, a dancer born with unique physical characteristics, and Tomona, a blind musician.
What is Inu-Oh?