Toxidromes
Antidotes
Tox Smells
Decontamination/Elimination
Potpourri
100
Somnolence, Miosis, Decreased respirations, Cool skin
What is opioid toxidrome; Think: heroin, oxycontin, methadone; Tx: naloxone
100
acetaminophen
What is n-acetyl cystine (NAC); Use the Rumack-Matthew nomogram; Must check 4-hour level!
100
Mint
What is oil of wintergreen & menthol
100
Time to administer activated charcoal for ingestions
What is within 1 hour
100
True or false: "Induce emesis with syrup of ipecac" is a good answer
What is FALSE! NEVER CHOSE THIS ONE! IT IS ALWAYS WRONG AND BAD!
200
Nausea/vomiting, Diarrhea, Lacrimation, Excessive secretions, Bradycardia, Bronchospasm, Bronchorrhea
What is cholinergic toxidrome (SLUDGE/DUMBELLS & Killer B's); Think: organophosphates; Tx: Atropine and 2-PAM
200
Cyanide
What is hydroxycobalamin; Think about in house fires with elevated lactate
200
Fruity
What is acetone, alcohols, nitrites
200
This unique method can be used to enhance salicylate elimination in toxic overdose
What is urinary alkalization
200
"Ketosis without acidosis"
What is isopropyl alcohol
300
Tachycardia, Hypertension, Mydriasis, Confusion, Warm/dry skin, Flushing
What is anticholinergic toxidrome; Think: diphenhydramine; Tx: physostigmine;
300
Acute iron poisoning
What is deferoxamine ; Always will have nausea/vomiting; Use for level >500
300
Bitter almonds
What is cyanide
300
Use of hemodialysis in overdose is best used for drugs with these three properties.
1. Low molecular weight, 2. Low protein binding, 3. Low volume of distribution; Examples: lithium, aspirin, alcohols, acidosis from metformin or others
300
What is TCA/Sodium channel blocker toxicity; Tx: Sodium bicarb
400
Somnolence/confusion, Hypotension, Normal pupils, Decreased respirations, Cool skin
What is sedative/hypnotic toxidrome; Think: Benzos; Tx: supportive
400
beta blockers and calcium channel blockers
What is glucagon and high-dose insulin
400
Garlic
What is arsenic, organophosphates
400
What do these have in common? Heavy metals, Alcohols, Caustics, Hydrocarbons
They don't bind to charcoal
400
What is bi-directional ventricular tachycardia associated with digoxin toxicity; Tx: dig FAB (digibind)
500
Tachycardia, Hypertension, Mydriasis, Diaphoresis, Agitation,
What is sympathomimetic toxidrome; Think: Cocaine; Tx: Benzos
500
isoniazid
What is pyridoxine (vitamin B6)
500
Wet hay
What is phosgene
500
With respect to elimination, what do these drugs have in common? Phenytoin, Carbamazepine, Phenobarbital, Quinine
Good candidates for multi-dose activated charcoal (MDAC) due to high enterohepatic circulation
500
This medication in overdose can cause profound, prolonged coma mimicking brain death.
What is baclofen; There are multiple case reports of patients awakening as preparations are being made for organ harvesting.