PHRD 511 PPP
In what class does trazodone belong to?
Antidepressant
The protein binding of cyclosporin A is higher than 95% because of:
The hydrophobic amino acid side chains
This term refers to a patient lying face upward:
Supine
The pKa of atorvastatin is about:
4
When aortic pressure is greater than ventricular pressure:
the aortic valve closes
What is the ideal blood glucose concentration range for a healthy adult when fasting?
70-99 mg/dL
What is the approximate Km for OATP1B1 transport of atorvastatin acid (Figure 1)?
1 micromolar
What GI hormone regulates the secretion of HCO3- (bicarbonate) from the pancreas?
Secretin
The type of epithelium that is found in the lining of the intestines and stomach and may be ciliated is known as:
simple columnar epithelium
What is the approximate IC50 for inhibition of OATP1B1 transport of atorvastatin by cyclosporin A (Figure 2)?
0.02 micromolar
LH is a 45-year-old female who comes to a community health fair for a routine blood pressure check. She reports no significant medical history and denies any symptoms. Her blood pressure reading today is 138/86. How should her blood pressure be classified?
Hypertension Stage 1
What is the approximate Vmax for OATP1B1 transport of atorvastatin acid (Figure 1)?
3.5 pmol/min/mg protein
During a heart contraction, the residual volume after an ejection is smaller than normal when:
outflow resistance decreases
Activation of the renin-angiotensin-aldosterone system will lead to which of the following:
sodium retention
If we identify two points A and B on someone's leg, and we know that A is distal to B, then what do we know about these two points?
B is closer to the hip, while A is farther away
RP is a 29 yo male who visits your pharmacy seeking a Varicella vaccine because he is planning to travel abroad, and his blood tests show he is not immune. He has no known allergies, is not currently ill, and has no contraindications to vaccines. He reports taking no chronic medications but consumes alcohol socially and occasionally uses e-cigarettes. His vaccine history includes all childhood vaccines through age 6, Tdap 5 years ago, an mRNA COVID-19 booster 6 months ago, and a recent flu shot this season. When would be the most appropriate time to administer the Varicella vaccine to RP?
Today
The protein binding of atorvastatin is:
Higher than 98% because atorvastatin is acidic and hydrophobic
In the overall cardiovascular control mechanisms, the sympathetic nervous system primarily influences:
peripheral resistance and stroke volume
Anna is a 52-year-old woman undergoing a routine diabetes screening. She has not been fasting. What is considered normal blood glucose levels for a random (non-fasting) plasma glucose test?
Random plasma glucose <140 mg/dL
Sarah, a 68-year-old postmenopausal woman, visits her physician for an evaluation of her bone health due to a family history of osteoporosis. The physician recommends a screening tool to assess her bone mineral density, following the WHO criteria for osteoporosis diagnosis. What tool should be used for screening?
Dual-energy X-ray Absorptiometry (DEXA/DXA)
David is a 5-year-old boy brought to the clinic for his first flu shot. His mother confirms that he has not previously received any influenza vaccines. What is the appropriate dosing schedule for him?
Two doses of 0.5 mL IM separated by at least 4 weeks
Atorvastatin lactone is not transported by OATP1B1 (Figure 1) because:
OATP1B1 substrates are usually weak acids that carry a negative charge at physiological pH
A person with a heart rate of 70 beats per minute and a cardiac output of 4.9 liters/min
has a stroke volume of 0.07 liters per beat
Which of the following are properties of cardiac muscle? Select all that apply.
A. found in many organs of the body
B. membrane is composed of gap junctions and intercalated disks
C. striated nature
D. multiple nuclei in each cell
B. membrane is composed of gap junctions and intercalated disks
C. striated nature
A denser connective tissue surrounding a fasciculus is called the __________.
perimysium