INTRO
What disease did this study focus on?
What is Crohn's disease?
This technology was used to analyze microbial signatures in the study
What is 16S rRNA sequencing?
This value is used to determine if the statistical tests are significant
What is 0.05?
These patients showed significantly more gut microbiome disbiosis compared to UC patients
What is crohn's disease patients?
What is dysbiosis?
This region was amplified by PCR to profile microbiome composition
What is the V4 region?
This data science platform was used in R to complete the statistical analysis
What is QIIME?
A certain large scale study in adult IBD patients was lacking
What is longitudinal microbiome studies?
These are two diseases that are types of Inflammatory Bowel Disease (IBD)
What is Crohn's Disease (CD) and Ulcerative Colitis (UC)?
What is every 3 months over a year?
This was used to compare the mean number of sequences of groups at various taxonomic levels
What is the Kruskal-Wallis one way test of variance?
A lower microbial diversity, a more disrupted community composition, and a greater microbiome instability are all symptoms of?
What is Gut Dysbiosis
What does this study aim to fill in the gap in current GI research?
What is defining a CD diagnostic microbiome signature?
What is sequence data analysis?
This was measured as a maker of intestinal inflammation in a subset of Spanish participants
What is Faecal Calprotectin Assay?
How many microbial groups were found to have formed a distinct microbial signature for CD diagnosis?
8
Lower in CD: Faecalibacterium, unknown Peptostreptococcaceae, Anaerostipes, Methanobrevibacter, unknown Christensenellaceae, Collinsella
Higher in CD: Fusobacterium, Escherichia