PK
This a term that describes the percentage of drug absorbed by the body.
What is bioavailability?
___ are drugs that bind to a cell's receptor in order to mimic the effects of a substance the body naturally produces that binds to the same receptor.
stimulant
neutralizer
antagonist
agonist
What is an agonist?
What is Foundations of Medical Practice?
CAT project, what does CAT stand for?
What is Critical Appraisal Topic?
What is mental status changes, autonomic hyperactivity, and neuromuscular abnormalities?
What is absorption, distribution, metabolism, and elimination/excretion?
Concerning drug receptor interactions, the constant Kd refers to:
What is the drug concentration required to occupy 50% of receptors (or the drug concentration that results in half-maximal physiological response)?
CAT project, what does CAT stand for?
What is a Critically Appraised Topic?
What does the P in PICO stand for?
Population of interest
This is the area where action potentials propagate via neurotransmitters.
What is synaptic cleft?
These 5 rules describes molecular properties important for a drug's pharmacokinetics in the human body. If these rules are broken, the molecule will likely have poor absorption and distribution.
What is Lipinski's rule of 5?
This term describes the activity of a receptor without any ligand bound (baseline activity).
What is Constitutive activity?
What is Ste. 211?
What does the OR symbol mean in PubMed?
What is this or that
A pt has been determined to have serotonin syndrome. What immediate treatment do you want to initiate? Name any you can think of.
1) Discontinue serotonergic agents
2) Sedate using benzodiazepines (eg, lorazepam 1 to 2 mg IV per dose; 0.02 to 0.04 mg/kg/dose in children): goal is to eliminate agitation, neuromuscular abnormalities (eg, tremor, clonus), and elevations in heart rate and blood pressure; titrate dose to effect
3) Provide: oxygen (maintain SpO2 ≥94); IV fluids; continuous cardiac monitoring
Your patient is taking clarithromycin that is metabolized by CYP3A4. What would happen to the amount of this drug when they take a CYP3A4 inhibitor?
Two drugs:
A:Kd =100nM
B:Kd =1nM
Which has higher affinity?
What is B: Kd = 1 nM?
In 2019, CMSRU received an award from the Association of American Medical Colleges (AAMC), the accrediting body for U.S. medical schools. What was this award?
What is the Spencer Foreman Award for Outstanding Community Engagement?
What does the [MeSH Terms] search strategy mean?
As seen with morphine, what type of metabolism adds large polar groups?
What is Phase II metabolism?
How is lipophilicity measured?
What is logP, the log of the partition coefficient?
EC50 mainly reflects a drug's:
What is potency?
Name the four principles that are the foundation of the Doctor of Medicine program at Cooper Medical School of Rowan University.
What is:
Educate. Innovate. Lead. Serve.
What instrument does Aleem play?
What is the harp?
This term defines a drug whose active form is a metabolite of that drug.
What is a prodrug?