Leukocytes
In general, WBCs attack these types of pathogens (name 2)
What are:
Bacteria
Viruses
Fungi
Foreign Substances
A condition characterized by increased eosinophils
What is Eosinophilia?
WBC Qualitative Changes occur in these two cellular components
What are the Cytoplasm and Nucleus?
The difference between describing a leukemia as chronic or acute in terms of blast count
What is:
acute > 20% blasts
chronic < 20% blasts
Myeloproliferative neoplasms are defined as the overproduction of what cells (3 categories)?
What are:
Red Blood Cells
Platelets
White Blood Cells
This WBC matures in the thymus
What is a T-cell?
A condition characterized by decreased neutrophils
What is Neutropenia?
Provide a condition that presents Dohle Bodies
What is:
1) Pregnancy
2) May-Hegglin Anomaly
3) Bacterial Infections
Auer rods are the hallmark of this leukemia
What is Acute Myeloid Leukemia (AML)
This MPD is characterized by elevated platelet
megakaryocyte count
What is Essential Thrombocythemia?
Name one thing eosinophils respond to
What are:
1) Allergies
2) Parasites
3) Hypersensitive Reactions
An exaggerated response to infection and inflammation characterized by a highly elevated WBC count
What is a Leukemoid Reaction?
A lipid storage disease characterized by a deficiency in hexosaminidase A
What is Tay-Sachs Disease?
This cancer is characterized by an intensely
basophilic cytoplasm and vacuolated blast cell called starry sky
What is Burkitt's Cell Lymphoma
The Philadelphia chromosome is present in 90% of
people with this leukemia.
What is Chronic Myeloid Leukemia (CML)?
List, in order, the monocyte maturation stages
What is:
1) Monoblast
2) Promonocyte
3) Monocyte
Provide two possible causes of lymphocytopenia
What are:
HIV
Malnutrition
Chemotherapy
Radiation
Renal Failure
This is the most common disease that shows variation in lymphocytes
What is Mononucleosis?
Children between the age group of 1-4 with leukemia most likely have this type
What is Acute Lymphoblastic Leukemia (ALL)?
This mutation is found in nearly every case of
Polycythemia Vera
What is the JAK mutation?
List, in order, the neutrophil maturation stages
What is:
1) Myeloblast
2) Promyelocyte
3) Myelocyte
4) Metamyelocyte
5) Band
6) Segmented Neutrophil
This is a chronic infection, mentioned in the slides,
known to cause monocytosis
What is Tuberculosis?
Describe one lymphocytic change in a patient
with HIV
What are reactive changes such as:
1) Extremely basophilic cytoplasm
2) Clefting
3) Vacuolization
The 4 main World Health Organization classifications of AMLs
What are:
AML with recurrent cytogenetic abnormalities
AML with myelodysplasia
Therapy-related AML and MDS
AML not otherwise categorized
Name all 6 Chronic Myeloproliferative Disorders (MPD)
What are:
Chronic Myelogenous Leukemia (CML)
Chronic Neutrophilic Leukemia (CNL)
Chronic Eosinophilic leukemia (CEL)
Primary myelofibrosis (IMF)
Polycythemia vera (PV)
Essential thrombocythemia (ET)