Compound heterozygosity for Hb S and Hb_ results in a disease that is less severe than SCD but more severe than sickle cell trait
What is Hb C
100
__________ is the only SSRI that does not block the metabolism of Tamoxifen by the hepatic 2D6 enzyme and is the drug of choice for depression in women with breast cancer
What is venlafaxine (Effexor)
100
This is the drug of choice to treat atrial fibrillation on patients with WPW
What is Procainamide
100
This is the most common adverse effect in the skin from prolonged topical steroid use
What is atrophy or striae
100
This is the skin rash most commonly associated with Celiac Sprue
What is dermatitis herpetiformis
200
This drug which increases Hb F has been shown to reduce the frequency of painful crises, reduce hospital admissions and improve mortality in SCD
What is Hydroxyurea
200
Unike Inflizimab which is 20% mouse protein, Adalimumab (Humira) is 100% ______ protein
What is human
200
This common anti-inflammatory drug, when used in acute pericarditis, can lead to an increased risk of recurrence
What are steroids
200
Prednisone is a prodrug that is converted to ____ in the liver
What is predisolone
200
Patients with sprue are at an increased risk for deficiency of this immunoglobulin
What is IgA
300
This syndrome includes fever, pulmonary infiltrates, hypoxemia, chest pain
What is acute chest syndrome
300
This is an orthopedic complication of long term Cipro use
What is Achilles tendon rupture
300
This drug has the same mechanism as clopidogrel (Plavix) but can be given IV and has a more rapid onset and higher degree of platelet inhibition
What is Prasugrel
300
In a patient without a previous diagnosis of adrenal insufficiency _____ is the preferred steroid because, in contrast to hydrocortisone, it is not measured in serum cortisol assays
What is dexamethasone
300
Patients with a positive IgA endomysial or transglutaminase antibody test should undergo a _______ _____ ______ for confirmation of the diagnosis
What is small bowel biopsy
400
There is an increased incidence of osteomyelitis with this organism in patients with sickle cell anemia resulting from infection of infarcted bone
What is Salmonella
400
In pregnant patients with Graves disease, PTU may be used but ____ may not be used
What is methimazole
400
Drugs which confer an increase in survival in patients with decreased left ventricular systolic function include ACE inhibitors, beta blockers, and ______
What is aldactone (or hydralazine and nitrates)
400
Anyone who has received a glucocorticoid dose comparable to more than 20 mg of prednisone a day for more than ______ weeks is at risk for HPA suppression
What is three weeks
400
Patients with sprue have a slightly increased risk of this malignancy
What is Non-Hodgkin Lymphoma
500
Because of ______ patients with SCD are at increased risk of infections with encapsulated organisms
What is functional asplenia
500
IV Ativan drips can lead to this acid base disorder
What is metabolic gap acidosis (propylene glycol)
500
CAD equivalents include carotid or peripheral atherosclerosis, diabetes, and _____
What is chronic kidney disease
500
Serum DHEA concentrations exhibit a circadian rhythm that reflects the secretion of (ACTH), while serum ______ concentrations do not exhibit a circadian rhythm because the plasma half-life is much longer
What is DHEA-S
500
Celiac disease is caused by a reaction to gliadin, a gluten protein found in wheat, and similar proteins found in the crops of the tribe Triticeae which includes other common grains such as ____ and ___