Renal Corpuscle
What two structures make up the renal corpuscle?
Glomerulus + glomerular capsule
What type of endothelium is in the glomerulus?
Fenestrated
T or F: small solutes pass into filtrate.
True
What does GFR stand for?
Glomerular Filtration Rate
What is renal autoregulation?
Kidney adjusts GFR without hormones/nerves
Where does filtrate collect?
Capsular space
What do the pores in the endothelium prevent?
Blood cells
Can glucose be filtered?
yes
Normal GFR?
125 mL/min
What happens to afferent arteriole when BP increases?
Constriction
What type of structure is the glomerulus?
Capillary network
What structure has a negative charge blocking proteins?
Basement membrane
Can blood cells be filtered?
no
What pressure favors filtration?
Blood hydrostatic pressure
What is tubuloglomerular feedback?
DCT signals afferent arteriole to adjust GFR
What happens to filtrate after capsular space?
Flows into renal tubule
What cells form filtration slits?
Podocytes
T or F: proteins can be filtered
False
Name ONE pressure opposing filtration
Capsular OR osmotic
What does sympathetic stimulation do?
Constricts afferent arteriole
What is the main function of the renal corpuscle?
Filtration of blood plasma
Name all 3 layers of the filtration barrier
Fenestrated endothelium, basement membrane, filtration slits
What size particles can pass?
< 3 nm
What determines GFR?
Net filtration pressure + filtration coefficient
What is the goal of hormonal control?
Raise BP and reduce urine output