Show:
Prostate Cancer 101
Hereditary Cancer
Prolaris
Myriad/Genetics 101
Misc.
100

What is the common blood test used to screen for prostate cancer?

PSA (Prostate Specific Antigen)

100

How many genes does the MyRisk Hereditary Cancer Test look at and how many corresponding different cancer sites?

48 and 11

100

What type of sample is Prolaris Biopsy Genomic Biomarker Ran on?

Prostate biopsy tissue that contains cancer.

100

What are the three types of cancer?

Hereditary, Familial, and Sporadic
100

What does ADT stand for? 

Androgen Deprivation Therapy

200

What procedure does a urologist perform to rule in or rule out prostate cancer when they have a patient referred to them with an elevated PSA?

In this procedure how many cores is usually taken? 

A Prostate Biopsy - 12

200

What is the name of the clinical study that talks about the prevalence of genetic mutations in metastatic prostate cance?

Pritchard - New England Journal of Medicine

200

How many genes does the prolaris test look at and what types of genes are they?

31 CCP and 15 housekeeping genes

200

What are the three tests that make up the Urosuite?

Prolaris, MyRisk, and Precise

200

What is the preferred treatment option for a NCCN Low Risk Patient?

AS

300
What is the name of the procedure a urologist will perform to examine the prostate for irregularities and derive a tumor stage?

DRE (Digital Rectal Exam)

300
What is the study that compares the outcomes of hereditary prostate cancer to sporadic prostate cancer? In the study how much more likely was a patient with a B1/B2 Mutation to die?

Castro - 6x more likely to die

300

What are the name of the 2 key validation studies in conservatively managed men? What was one of the key take aways? 

Cuzick 1 and 2

Prolaris was 2x more prognostic than PSA and Gleason.

Prolaris was able to better stratify an inidivuals mortality risk

Conservatively managed patients

300

What is the name of the part of the MyRisk result that helps a patient understand how to screen for additional risks? 

MyRisk Management Tool

300

What was the Schreiber study and what was one key take away?

Comparing Biopsy Gleason score to final path. Only agree 55% of the time
400
When determining a patient Gleason Score there are two numbers. How do we refer to these two numbers. i.e. What is the first number called what is the second number called? 

Primary and Secondary - Ex. 3+4=7 , Primary 3 secondary 4. 

400

What are the two NCCN affected patient criteria for germline testing that do not require any additional family history?

Metastatic and NCCN Very High / High Risk

400

What is the AS threshold set at? What is the Multi-Modal Threshold set at? 

What study validated the AS Threshold? What Studies validated the MM Thresholds?

3.2% and 8.9%

Lin AS Threshold Validation & Tward 1 & 2

400

What are the three red flags for hereditary cancer?

Young, Rare, Multiple

400

What was the Epstein Study looking at and what was one of the main takeaways?

10 top GU pathologists looking at standard slides, only agreed 66% of the time. 

Bonus : Patient Case E!

500

What are the five critical clin/path features of the workup of prostate cancer?

Age, Percent cores positive, Pre-Biopsy PSA, Tumor Stage (DRE), Gleason Score

500

What are the 4 main clinical utility points for affected Prostate cancer patients and hereditary cancer testing? 

PARPi, Secondary Cancer Risks, More aggressive Cancer, Impact on Family

500

What are the three main endpoints of the Prolaris result? What is the fourth feature of the test?

10-year DSM with Conservative management

10-year risk of Mets with Surgery or RT

10-year Risk of Mets with RT + ADT

ARR - benefit of adding ADT to RT

500

What year was Myriad Genetics founded? 

1991

500

What NCCN Risk Categories does Medicare cover for Prolaris testing? 

All Risk Categories