ASCENT or PERCENT
ADC-ME/ADC-YOU
There’s Something about Pink
TERMINOLOGY
TROPiCS-02 and Topics
100

The number of patients randomized in the ASCENT study and criteria for how many chemotherapies for advanced disease to be included in study

What is 529 and ≥2?

100

Dosing of this ADC is 5.4 mg/kg q3 weeks  

What is trastuzumab dxd (Enhertu)?

100

Breast cancer awareness month.

What is October?

100

The acronym GILD stands for ____

What is the Gilead Nasdaq Stock Symbol?

100

Regarding TROPiCS-02: at least 2, but no more than 4, lines of chemotherapy for metastatic disease

What is part of the study inclusion criteria?

200

tNBC accounts for this many of all breast cancer cases

What is 10%?

200

This study of single agent datopotomab dxd is a direct competitor to ASCENT-3

What is TB-02?

200

The reason that the ribbon is pink for breast cancer.

What is soothing comforting and healing?

200

Another name for DS-8201

What is tratuzumab deruxetecan, enhertu?

200

–Visceral metastases (yes/no)  

–Endocrine therapy in metastatic setting ≥6 months (yes/no)  

–Prior lines of chemotherapy for metastatic disease (2 vs 3 or 4)  

What are stratification factors for TROPiCS-02?

300

The 2 adverse events that are in the Black Box warning in the Trodelvy product label

What is neutropenia and diarrhea?

300

These assays were used in DB-04 for enrollment screening

What is VENTANA HER 4B5 IHC and INFORM HER2 dual IHC?

300

The American singer Alecia Beth Moore Hart is also known by this stage name.

Who is Pink?

300

The acronym DSE stands for ____

What is Disease Status Evaluation Visit?

300

In a post-hoc subanalysis, PFS outcomes for SG vs single-agent chemotherapy in the HER2 IHC0 and HER2-low subgroups are consistent with this population

What is the TROPiCS-02 ITT population?

400

G-CSF was used in this percentage of patients in the ASCENT study

What is 44%?

400

Which ADC contains belotecan as its payload

What is sacituzumab tirumotecan (SKB264)?

400

Approximately 1 in ____ U.S. women are going to develop invasive breast cancer in the course of their life.

What is 8?

400

What the HOPE in Project HOPE stands for

What is Hematology-Oncology Portfolio Engagement?

400

In the result of the EORTC QCQ-30 questionnaire “SG delayed TTD of global health status/QOL and fatigue compared with single-agent chemotherapy,” This is TTD

 What is Time to Deterioration (or time from randomization to the first date a patient achieved ≥10-point deterioration from baseline or died due to any cause, whichever occurred first)

500

The median OS improvement in the Brain met negative population in ASCENT

What is mOS BrMet–: 12.1 vs 6.7 months (HR=0.48, 95% CI: 0.38–0.59); 5.4 months?

500

The study SOLTI VALENTINE will test this ADC alone or in combination with endocrine therapy as neoadjuvant tx for early HR+/Her2 - BC

What is patritumab deruxtecan?

500

One of these is not a “Pink Lady” type of flower: a cocktail, a hospital volunteer, a fast passenger liner crossing the Atlantic

What is Atlantic Crossing? (that was a Blue Riband)

500

This molecular breast cancer subtype pathology will read ER+/PR-/HER2 -

What is Luminal B? 

 

500

The response to: “For HR+/HER2- mBC, should Trodelvy be sequenced before or after Enhertu?”

What is “There are currently no sequencing data available with respect to Trodelvy –> Enhertu or Enhertu -> Trodelvy in HR+/HER2- mBC”