Dosing and Administration
What is 150mg, 300 mg, 450mg, and 600mg?
3 dosing strengths of Vafseo
What is 3923?
The number of patients enrolled in both studies.
What are
Stabilizes cellular HIF levels
Stimulates the body's response to hypoxia
Increases endogenous EPO production
The 3 physiologic effects of Vafseo
What is 2-3 hours?
What is once every 4 weeks?
The frequency you can titrate up Vafseo
What is less than 1%
The % of patients that had hepatocellular injury attributed to Vafseo.
What is the first occurrence of a cardiovascular event (MACE) pooled across the trials?
The primary safety endpoint of the studies.
What is a hypoxia-inducible factor prolyl hydroxylase inhibitor indicated for the treatment of anemia due to chronic kidney disease in adults who have been receiving dialysis for at least 3 months?
The indication for Vafseo.
What is 9.2 hours?
The mean half-life of Vafseo.
What is 600 mg?
The maximum dose of Vafseo
What is 14%?
The % pf Vafseo patients with worsening hypertension in Innovate 1 and Innovate 2.
What is the mean change in hemoglobin from baseline to week 24 to 36 and from baseline to weeks 40 to 52?
The primary efficacy endpoint of the study.
What is increased risk of death, myocardial Infarction, Stroke, Venous Thromboembolism, and Thrombosis of Vascular Access?
The black box warning for Vafseo.
What is 10 g/dl - 11 g/dl?
The target Hb range for Vafseo.
What is 11 g/dl?
The Hb level you should interrupt dosing Vafseo
What is 13%?
The % of Vafseo patients that experienced diarrhea.
What is 18.2% vs 19.3%?
What is:
Pediatric population
Hepatic Impariment
Nursing Mothers
Patients who should not take Vafseo.
What is the West Area?
The world's greatest team ever!!
What is 14 days after last dose?
Wait time when switching from Mircera to Vafseo.
The % of patients that discontinued Vafseo do to gastrointestinal symptoms.
What are:
> 18 years of age
DDCKD
Ferritin concentration > 100 ng/ml
TSAT of at least 20%
No blood transfusions within last 8 weeks
Hb concentrations b/w 8-11 g/dl in the US?
The inclusion criteria for both trials.
What are ALT, AST, and Bilirubin?
Liver testing to be completed prior to starting Vafseo.
What are:
Iron supplements and phosphate binders
OAT1 & OAT2 inhibitors
BCRP substrates
Statins?
The drug interactions of Vafseo.